摘要
目的探讨ＮＯＳ活性与雄激素在阴茎勃起中的关系。方法将３０只成年雄性大白鼠随机分为去势组，替代组及对照组，去势组与替代组分别切除双侧睾丸，其中替代组在切除睾丸后给予睾酮替代。于术后１周取阴茎组织，用紫外分光光度法检测其ＮＯＳ活性。结果去势组ＮＯＳ活性较对照下降７０％（Ｐ＜０．０１），睾酮替代组和对照组ＮＯＳ活性差异无显著性（Ｐ＞０．０５）。结论雄激素可能通过调节ＮＯＳ活性而在阴茎勃起中发挥重要作用。
Objective To investigate whether the NOS activity is associated with
androgen in penile erection. Methods Thirty mature male rats were randomly divided into 3
groups:unoperated controls,castrates,castrates given testosterone (T) replacement. One week
after castration,NOS activity in penile tissue were detected with ultraviolet spectrophotometry.
Results The NOS activity in controlscastrates and castrates with T replacement was
(1.440.37)nmolg-1min-1(0.43 0.31)nmolg-1min-1 and (1.370.37)nmolg-1min-1, respectively.
Compared with controls, the NOS activity in castrates decreased by 70%(P<0.01).But there is no
significant difference in NOS activity between controls and castrates with T
replacement(P>0.05). Conclusions It was suggested that androgen plays an important role on
penile erection through regulating NOS activity.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1999年第6期370-371,共2页
Chinese Journal of Urology
