摘要
目的探讨血清甲胎蛋白、可溶性细胞间黏附分子-1及高尔基体膜蛋白-73在肝细胞肝癌(HCC)中的诊断价值。方法住院患者221例中原发性肝癌44例,其他肝恶性肿瘤14例,肝良性疾病74例,非肝脏疾病49例及健康献血者40例,用酶联免疫吸附试验(ELISA)测定各组血清中高尔基体膜蛋白-73及可溶性细胞间黏附分子-1,用荧光ELISA测定各组血清中甲胎蛋白含量。结果甲胎蛋白、可溶性细胞间黏附分子-1及高尔基体膜蛋白-73联合检测可使原发性肝癌的检出敏感性和特异性分别达86%和93%,高于其中任一单项检测,可明显提高HCC患者的阳性率。结论 3项联合检测对诊断HCC具有重要临床价值。
Objective To study the clinical significance of serum alpfa-fetoprotein（AFP） soluble intercellular adhesion moleculer-1（sICAM-1） and Golgiprotein-73（GP73） in diagnosing hepatic cellular carcinoma.Methods 221 cases of patients including 44cases of hepatic cellular carcinoma,14 cases of other hepatic carcinoma,74 cases of hepatic benign diseases,49 cases of unhepatic diseases and 40 cases of nomal controls were determined,and 73 were determined with double antibody enzyme linked immunosorbent assay alpha-fetoprotein were determined with fluorescent enzyme linked immunosorbent assay.Results Combined detection of alpha-fetoprotein、soluble intercellular adhesion molecule-1and Golgiprotein 73 enhanced the sensitivity of heapticellular carcinoma diagnosis to 86% and the specificity to 93%,which are higher than those of any single tumor marker,and obviously upgrade the rate of determined diagnosis.Conclusion The combined detection of three markers has clinical value in diagnosing the hepatic cellular carcinoma.
出处
《检验医学与临床》
CAS
2010年第21期2305-2306,共2页
Laboratory Medicine and Clinic
基金
广西卫生厅重点科研课题资助(No.200883)
