摘要
目的：探讨去甲斑蝥素泊洛沙姆４０７在肿瘤临床治疗中应用的可行性。方法：选择２５例原发性肝癌者Ｂ超引导下经皮肝穿刺，每次肝癌肿块内直接注入去甲斑蝥素泊洛沙姆４０７缓释制剂２ｍｌ，治疗１～４次，注射前后查血常规、肝功能、肾功能、血脂，并根据ＷＨＯ制定的药物毒副反应分级标准的要求观察毒副反应程度。结果：治疗过程中除有发热及血清谷丙转氨酶一过性增高外，外周血常规、肾功能、血脂均无明显变化。结论：去甲斑蝥素泊洛沙姆４０７局部注射治疗肝癌是安全可行的。
Objective: To determine the availability of norcantharidinpoloxamer 407 used to treat cancer in clinic. Methods: The bloodroutine,liver function,renal function,bloodlipid of 25 patients with primilar liver cancer were examinated before and after norcantharidinpoloxamer 407 was injected in tumor under B ultrasonicin,and the toxicityside effect of norcantharidinpoloxamer 407 was oberserved. Result: Fever was found in 11 cases,and glutamicpyruric transaminase activity in serum was high temporarily;but preipheral blood counts,renal function,blooklipid didn't change in all cases. Consulusion: norcantharidinpoloxamer 407 is safe for using in intratumorl administration ,and poloxamer 407 may attenuate toxicity of norcantharidin.
出处
《安徽中医学院学报》
CAS
1999年第3期11-13,共3页
Journal of Anhui Traditional Chinese Medical College
关键词
去甲斑蝥素
泊洛沙姆
毒副反应
抗癌药
局部注射
Norcantharidin
Poloxalene
Drug toxicityside effect
Liver neoplasm,Interventionaltherapy
