摘要
[目的]观察依帕司他联合莫沙必利治疗糖尿病神经源性膀胱的临床疗效.[方法]36例糖尿病神经源性膀胱患者,予依帕司他150 mg/d、莫沙比利15～30 mg/d治疗2周,比较治疗前后B超测定膀胱残余尿量的变化及疗效.[结果]治疗后B超测定的膀胱残余尿量较治疗前明显减少（t=4.907,P〈0.01）,显效率75%,总有效率 91.67% ;3例患者治疗后膀胱残余尿仍多于200 mL,最终作膀胱造瘘.治疗过程中出现轻度胃肠道不适5例,均于停药后缓解.[结论]依帕司他联合莫沙必利治疗糖尿病神经源性膀胱疗效良好,不良反应少.
[Objective] To observe the clinical efficacy of epatrestat combined with mosapride in the treat ment of diabetic neurogenie bladder. [Methods] A total of 36 patients with diabetic neurogenic bladder were treated with epalrestat（150mg/d） and mosapride（15-30mg/d） for two weeks. The changes of residual urine volume of bladder measured by B-ultrasound were compared before and after treatment, and the efficacy was observed. [Results] Compared with before therapy, the residual urine volume of bladder after therapy significantly decreased（t =4.907,P〈0.0）. The excellence rate and total effective rate were 75% and 91.67%, re spectively. Three patients whose residual urine volume was still more than 200mL after the treatment underwent cystostomy at last. Five patients had mild gastrointestinal symptoms during the treatment and the relief of symptoms after drug withdrawal. [Conclusion] Epalrestat combined with mosapride has good effect for the treatment of diabetic neurogenic bladder with rare adverse reactions.
出处
《医学临床研究》
CAS
2010年第10期1809-1810,1814,共3页
Journal of Clinical Research
