摘要
目的观察中药红景天对实验性血管性痴呆(VD)大鼠血中超氧化物歧化酶(SOD)、丙二醛(MDA)及大脑海马组织白细胞介素1β(IL-1β)的影响。方法采用双侧颈总动脉永久性结扎法,造成大鼠慢性脑灌注不足所致VD模型。术后治疗组给予红景天5g.kg-1.d-1、对照组予尼莫地平20mg·kg-1.d-1灌胃,假手术组与空白模型组以蒸馏水1mL.100g-1灌胃。检测各组大鼠血中SOD、MDA及大脑海马组织IL-1β含量。结果红景天和尼莫地平均可以升高大鼠血中SOD活性、降低MDA含量,降低大脑海马组织IL-1β的含量,与模型组比较,差异均有统计学意义(P<0.05)。而红景天组与尼莫地平组以上指标含量比较,差异无统计学意义(P>0.05)。结论红景天可能通过清除自由基、抗脂质过氧化功能和抑制IL-1β的过度表达对实验性血管性痴呆有一定的防治作用。
Objective：To explore the impacts of rhodiola on SOD and MDA levels in blood and IL-1β in hippocampus tissue in the rats with vascular dementia（VD）.Methods：Bilateral occlusion of common carotid arteries was applied to induce chronic perfusion insufficiency of the brain and prepare VD model in rat.After operation,the rats in treatment group were treated with rhodiola,5 g·kg-1·d-1,those in control group was treated with gastric infusion of nimodipine,20 mg·kg-1·d-1;and those in sham-operation group and blank model group were administered with distilled water,1 mL/100 g.The levels of SOD and MDA in blood and IL-1β in hippocampus tissue were determined in each group.Results：Either rhodiola or nimodipine could increase SOD activity and decrease MDA content in blood,as well as reduce the content of IL-1β in brain hippocampus tissue in rats,which indicated statistical significant difference as compared with model group（P0.05）.There were no statistical significant differences in the above indexes in comparison between rhodiola group and nimodipine group（P0.05）.Conclusion：Rhodiola acts on the protection to certain extent from experimental VD through removing free radical,against lipid peroxidation and inhibiting over-expression of IL-1β.
出处
《世界中西医结合杂志》
2010年第10期846-848,共3页
World Journal of Integrated Traditional and Western Medicine
基金
山西省卫生厅资助项目(No.200745)
