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学龄前儿童原发垂体性生长激素缺乏症的MR影像学表现 被引量:1

MR findings of idiopathic pituitary growth hormone deficiency in preschool children
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摘要 目的:研究学龄前儿童原发垂体性生长激素缺乏症垂体的MRI特征。方法:回顾分析46例原发垂体性生长激素缺乏症儿童(病例组)垂体的MR影像特征,并与35例同龄健康儿童(对照组)作对照比较。结果:病例组腺垂体平均高度(2.32±0.78)mm,与脑干对比,34例T1WI信号低于脑干,12例信号与脑干相等;44例垂体柄完整连续,矢状面平均宽径(0.89±0.51)mm;2例垂体柄缺如;2例垂体后叶异位于下丘脑漏斗底部的正中隆起。4例合并中枢神经系统畸形。对照组腺垂体高度、垂体柄宽径分别为(3.76±1.21)mm、(1.64±0.59)mm。病例组腺垂体高度、垂体柄矢状宽径均比正常对照组小,差异具有显著性意义。结论:MRI能够清楚的显示原发垂体性生长激素缺乏症垂体的影像学特征,表现为垂体前叶变小,信号低于或等于脑干,垂体柄变细或缺如,大多数垂体后叶位置正常,少数病例后叶异位,以及合并的中枢神经系统畸形。 Objective:To describe the MR characteristics in preschool children with idiopathic pituitary growth hormone deficiency (IPGHD).Methods:MR images of 46 preschool-age children with IPGHD (study group) were reviewed retrospectively.The MR findings of the study group were compared with those of 35 healthy children at the same age (control group).Results:In the study group,the height of pituitary gland was (2.32±0.78)mm.The signal intensity of adenohypophysis was isointense to brainstem in 12 cases and hypointense in 34 cases on the T1-weighted images.The pituitary stalks were complete and continuous in 44 patients,the width of which were (0.89±0.51)mm on sagittal images and absent in two patients.The posterior pituitary was ectopic in 2 cases.Four patients were found to have midline central nervous system malformations.The height of pituitary gland and the width of pituitary stalks were (3.76±1.21)mm and (1.64±0.59)mm respectively in the control group,the difference of which were statistically significant (P0.05) compared with the study group.Conclusion:MR imaging can clearly show the pituitary abnormalities in patients with IPGHD,including a small and hypointensive signal of anterior pituitary lobe to brainstem,a small or absent pituitary stalk,an ectopic posterior pituitary and central nervous system malformation.
出处 《放射学实践》 北大核心 2010年第10期1090-1093,共4页 Radiologic Practice
关键词 人生长激素 侏儒症 垂体性 垂体 磁共振成像 儿童 学龄前 Human growth hormone Dwarfism pituitary Pituitary gland Magnetic resonance imaging Child preschool
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参考文献14

  • 1Hamilton J,,Blaser S,Daneman D,et al.MR imaging in idiopathic growth hormone deficiency[J].AJNR,1998,19(9):1609-1615. 被引量:1
  • 2Elster AD,Chen MY,Williams DW,et al.Pitutiary gland:MR imaging of physiologic hypertrophy in adolescence[J].Radiology,1990,174(3):681-685. 被引量:1
  • 3林光武,张涛,杨宁,蔡丰,史轶蘩,邓洁英,张逻东,姜亚云.正常青少年垂体MRI研究[J].中华放射学杂志,2005,39(10):1022-1027. 被引量:39
  • 4Argyropoulou MI,Kiortsi DN.MRI of the hypothalamic-pituitary axis in children[J].Pediatr Radiol,2005,35(11):1045-1055. 被引量:1
  • 5陈凤生,王伟主编..儿科内分泌遗传代谢疾病临床新技术 性腺及性发育部分[M].北京:人民军医出版社,2002:167.
  • 6高雅君,徐和平,何四平.原发垂体性生长激素缺乏儿童垂体形态学的MRI研究[J].医学临床研究,2008,25(9):1566-1568. 被引量:4
  • 7舒安利,李海琴,戴前容,张君.遗传性垂体性侏儒症家系的调查[J].中国优生与遗传杂志,2006,14(2):111-111. 被引量:2
  • 8Osorio MG,Marui S,Jorge AA,et al.Pituitary magnetic resonance imaging and function in patients with hormone deficiency with and without m utations in GHRH R,GU-1 or PROP-1 genes[J].J Clin Endocrinol Metab,2002,87(11):5076-5084. 被引量:1
  • 9Arends NJ,Vd Lip,Robben SG,et al.MRI findings of the pituitary gland in short children born small for gestational age (SGA)in comparison with growth hormone deficient (GHD) children and children with normal stature[J].Clin Endocrinol (Oxf),2002,57(6):719-724. 被引量:1
  • 10Kornreich L,Horev G,Lazar L.MR findings in growth hormone deficiency:correlation with severity of hypopituitarism[J].AJNR,1998,19(8):1495-1499. 被引量:1

二级参考文献37

  • 1陶晓峰,施增儒,朱杰明,陈瑞冠,叶军.原发性垂体性侏儒11例鞍区MRI和CT检查对照研究[J].第二军医大学学报,1993,14(3):269-272. 被引量:2
  • 2林光武(综述),杨宁,张涛(审校).正常垂体MRI改变与激素水平变化相关性研究[J].实用全科医学,2005,3(1):68-69. 被引量:6
  • 3林光武,张涛,杨宁,蔡丰,史轶蘩,邓洁英,张逻东,姜亚云.正常青少年垂体MRI研究[J].中华放射学杂志,2005,39(10):1022-1027. 被引量:39
  • 4刘影,李传福,张杨,孟祥水,侯金文,张凯,郑金勇,丛培新.垂体柄阻断综合征的MRI诊断[J].中华放射学杂志,2006,40(3):324-325. 被引量:40
  • 5Elster AD, Chen MY, Williams DW 3rd, et al. Pitutiary gland: MR imaging of physiologic hypertrophy in adolescence. Radiology, 1990, 174:681-685. 被引量:1
  • 6Tsunoda A, Okuda O, Sato K. MR height of the pituitary gland as a function of age and sex: especially physiological hypertrophy in adolescence and in climacterium. AJNR, 1997, 18:551-554. 被引量:1
  • 7Elster AD, Sanders TG, Vines FS, et al. Size and shape of the pituitary gland during pregnancy and post partum: measurement with MR imaging. Radiology, 1991, 181:531-535. 被引量:1
  • 8Denk CC, Onderoglu S, Ilgi S, et al. Height of normal pituitary gland on MRI: differences between age groups and sexes. Okajimas Folia Anat Jpn, 1999, 76:81-87. 被引量:1
  • 9Sharafuddin MJ, Luisiri A, Garibaldi LR, et al. MR imaging diagnosis of central precocious puberty : importance of changes in the shape and size of the pituitary gland. AJR , 1994, 162:1167-1173. 被引量:1
  • 10Suzuki M, Takashima T, Kadoya M, et al. Height of the normal pituitary gland on MR imaging: age and sex differentiation. J Comput Assist Tomogr, 1990, 14:36-39. 被引量:1

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