摘要
[目的]探讨慢性前列腺炎临床症状和逼尿肌功能改变之间的关系。[方法]取雄性SD大鼠,随机分为对照组10只和模型组20只,建立免疫性慢性非细菌性前列腺炎大鼠模型,膀胱穿刺充盈性膀胱测压,观察膀胱压力、容量变化及逼尿肌不稳定的发生情况。[结果]对照组无逼尿肌不稳定发生。模型组逼尿肌不稳定发生率70%,不同前列腺组织病理分级中逼尿肌不稳定发生率无明显差别。对照组与模型组大鼠膀胱容量、最大逼尿肌压和残余尿量分别为(0.57±0.06)与(0.39±0.05)mL、(27.3±1.87)与(22.8±2.03)cmH2O和(0.11±0.04)与(0.33±0.06)mL。两组比较差异有显著性意义(P<0.05)。[结论]慢性非细菌性前列腺炎模型大鼠可出现与前列腺组织学改变程度关系不确定的逼尿肌功能改变,其机制有待进一步研究。
【Objective】 To evaluate the relationship between the change of detrusor function and the pathological changes of the chronic prostatitis（CP）.【Methods】 Thirty male SD rats were divded into control group（10） and model group（20） randomly,and the experimental CAP rat model was made by using purified prostate protein twice with immune adjuvant,then punctio vesicae was performed later,followed by a filling cystometry.The bladder pressure,capacity changing and the probability of detrusor instability were observed respectively.【Results】 No detrusor instability was detected in control group.Detrusor instability ratio of the experiment group was 70%,the bladder capacity and the maximum detrusor pressure decreased from（0.57±0.06） mL and（27.3±1.87） cmH2O in the control group to（0.39 ±0.05） mL and（22.8±2.03） cmH2O in the model group respectively（P〈0.05）.The residual urine volume increased from（0.11±0.04） mL to（0.33±0.06） mL（P〈0.01）.【Conclusion】 The lower urinary tract symptom of chronic prostatitis is related to the detrusor instability,but the relationship between prostate histology and the detrusor function is ambiguous.To know the correlation factors do significant benefit in guiding the clinical treatment.
出处
《大连医科大学学报》
CAS
2010年第5期512-515,共4页
Journal of Dalian Medical University
