摘要
目的：探讨输注随机单一供者血小板（ＳＤ）与输注随机多供者血小板（ＭＤ）疗效的比较。方法：对接受血小板输注的住院病人，ＳＤ组７８例和ＭＤ组３５例，采用淋巴细胞毒试验（ＬＣＴ），血小板校正增加值（ＣＣＩ）计算，进行疗效比较。结果：ＭＤ组的人类组织相容性抗原（ＨＬＡ）和抗体强度明显高于ＳＤ组（Ｐ＜００１），ＣＣＩ值明显低于ＳＤ组（Ｐ＜００１）。结论：输注随机单一供者血小板比输注随机多供者的血小板，无论在同种免疫性抗体形成的比例，还是在减少血小板输注无效率和预防同种免疫反应的产生。
Objective: To compare the therapeutic effectiveness of random single donor (SD) platelet transfusion and random multiple donor (MD) platelet transfusion. Methods: The hospitalized patients who were treated with platelet transfusion were studied to compare the therapeutic effectiveness in SD group (78 cases) and in MD group (35 cases) with lymphocytotoxicity test (LCT) and calculation of corrected count increment of platelet (CCI). Results: Antibody and antibody potency of human histocompatibility antigen system (HLA) were obviously higher in MD group than that in SD group ( P <0 01), CCI in MD group was obviously lower than that in SD group ( P <0 01). Conclusion: SD platelet transfusion is evident different than MD platelet transfusion, either in reducing alloimmune antibody formation, or in decreasing refractoriness of platelet transfusion and in preventing alloimmune response.
出处
《中山医科大学学报》
CSCD
1999年第2期144-146,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
