摘要
目的:观察生长抑素联合抑肽酶治疗急性重症胰腺炎的临床疗效。方法:将急性重症胰腺炎患者48例随机分为两组:A组和B组,A组患者在常规治疗基础上加用生长抑素联合抑肽酶治疗,B组患者在常规治疗基础上加用生长抑素。比较两组患者的腹痛、腹胀缓解时间、血淀粉酶恢复正常时间、WBC恢复正常时间以及感染率、病死率、并发症发生率、住院时间和住院费用。结果:A组患者腹痛、腹胀缓解时间、血淀粉酶恢复正常时间、WBC恢复正常时间较B组明显缩短,感染率、病死率、并发症发生率、住院时间及住院费用较B组明显降低。结论:生长抑素联合抑肽酶治疗急性重症胰腺炎效果明显,可较早缓解症状并缩短病程、降低感染率、病死率、并发症发生率从而缩短住院时间,降低住院费用。
Objectives： To evaluate the curative effect of combination of somatostatin and protease inhibitor in the treatment of severe acute pancreatitis. Methods：48 patients with SAP were randomlv divided into two groups, group A and group B, Both groups were treated by the conventional mode of therapy. Patients in the group A were treated with Somatostatin and Protease Inhibitor, Patients in the group B were treated with Somatostatin. The release time of abodominal pain and distention, the recovery time of serum amylase and white blood cel1 count（WBC）. The time of hospital stay , cost of treatment in hospital, the infection rate, the death rate and the com- plications rate of two groups were compared. Results：The release time of abodominal pain and distention, the recovery time of serum amylase and white blood cel1 count （WBC） of group A were significantly shorter than that of group B. The time of hospital stay, the infection rate,the death rate,the complications rate and cost of treatment in hospital of group A were significantly shorter than that of group B. Conclusions：The effect of combination of Somatostatin and Protease Inhibitor treatment on severe acute pancreatitis was significant,it can remising syndrome, shortening course of treatment, reduce the infection rate, the death rate,the complication rate, length of stay and cost of treatment in hospital.
出处
《现代生物医学进展》
CAS
2010年第19期3700-3702,共3页
Progress in Modern Biomedicine
关键词
急性重症胰腺炎
生长抑素
抑肽酶
severe acute pancreatitis； Somatostatin； Protease Inhibitor；
