摘要
目的研究食管鳞癌组织中Bmi-1蛋白表达情况及其与食管鳞癌临床病理特征的关系。方法采用免疫组织化学方法分别检测Bmi-1蛋白在30例食管鳞癌、癌旁组织中的表达情况,分析其与食管鳞癌临床病理特征的关系。结果 Bmi-1蛋白在食管鳞癌、癌旁组织中的表达率分别为26.6%和6.6%,Bmi-1蛋白在食管鳞癌中的表达高于癌旁组织。Bmi-1蛋白表达与浸润深度及TNM分期密切相关(P<0.05),而与患者性别、年龄、肿瘤大小及淋巴结转移无关(P>0.05)。结论 Bmi-1蛋白表达与肿瘤进展相关,食管鳞癌组织中Bmi-1蛋白的高表达是判断食管鳞癌患者预后不良的参考指标。
Objective To investigate the expression and siguifieance of Bmi-1 in esophageal squamous cell carcinoma（ESCC）. Methods The samples from 30 ESCC patients, adjacent non-cancerous tisseus were also used in this study. The expression of Bmi-1 protein was detected by immunohistochemistry, and clinicopathological features were analyzed. Results The positive rate of Bmi-1 in ESCC was 26.6%. The positive rate of Bmi-1 in adjacent non-cancerous was 6.6%. The overexpression of Bmi-1 protein in ESCC was obviously associated with invasive depth and TNM stage（P 〈0.05） , but not with gender, age, tumor size and lymph nodemetastasis （P 〉 0.05）. Conclusions The intensive expression of Bmi-1 in ESCC is related to tumor progression. The increasing expression of Bmi-1 is useful to predict poor prognosis of ESCC.
出处
《中国肿瘤外科杂志》
CAS
2010年第5期279-281,共3页
Chinese Journal of Surgical Oncology
关键词
食管鳞癌
Bmi-1表达
免疫组织化学
预后评价指标
esophageal squamous cell carcinoma
Bmi-1 expression
immunohistochemistry
prognostic indicators
