摘要
丙型肝炎病毒(hepatitis C virus,HCV)急性感染后可引起机体一系列固有及适应性免疫反应.约有15%-25%的HCV感染可被宿主免疫反应所自限清除,而大多数则呈慢性持续性感染,发展为慢性活动性肝炎、肝硬化及肝细胞癌.大量研究证实宿主遗传基因的多态性可能会导致机体免疫功能状态的差异,进而影响到HCV感染的不同临床结局.本文主要对相关的潜在基因多态性与HCV感染转归的关系进行综述.
Acute hepatitis C virus （HCV） infection can induce host innate and adaptive immune responses. Approximately 15%-25% of HCV-infected patients successfully eliminated the virus whereas the majority of these patients developed chronic liver disease, cirrhosis and hepatocellular carcinoma. Numerous studies have demonstrated that host genetic polymorphisms may lead to differences in host immune function and therefore influence the clinical outcome of HCV infection. This review briefly summarizes the relationship between host genetic polymorphisms and the outcome of HCV infection.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第26期2731-2738,共8页
World Chinese Journal of Digestology
基金
国家科技重大专项课题基金资助项目
No.2009ZX1004904~~
关键词
丙型肝炎病毒
感染
基因
多态性
转归
Hepatitis C virus
Infection
Gene
Polymorphism
Outcome
