摘要
骨关节炎(osteoarthritis,OA)是一种常见的关节退行性疾病,严重影响人类健康。近年研究显示,软骨细胞过度凋亡在OA的发病中产生了重要影响。软骨细胞凋亡的机制目前尚不明确,一般认为,体内外各种凋亡诱导因子通过刺激细胞内多条信号转导通路,导致下游凋亡途径的激活,最终大多汇集为caspase级联放大反应这一共同通路。阐明关节软骨细胞凋亡的机制,将有助于OA的防治。为此,本文针对这方面的研究现状作了简要的综述。
Osteoarthritis （OA） is one of the most common article degenerative diseases that seriously affect human health. Recent studies have shown that excessive apoptosis of the chondrocyte plays an important role in the pathogenesis of OA. The mechanism of the chondroeyte apoptosis is unclear yet. It is thought that exterior and interior apoptosis inducing factors activate down-stream apoptosis pathway through the stimulation of multiple intracellular signal transduction pathways, and eventually through caspase cascade. The elucidation of the apoptosis mechanism of the chondroeyte can contribute to the prevention and treatment of OA. This paper reviews the recent research progress in the field.
出处
《中国骨质疏松杂志》
CAS
CSCD
2010年第10期776-780,共5页
Chinese Journal of Osteoporosis
基金
国家自然科学基金资助项目(30972556
30630058)
教育部博士点基金资助项目(20090201110049)
关键词
软骨细胞
凋亡
信号转导
骨关节炎
Chondroeyte
Apoptosis
Signal transduetion
Osteoarthritis
