摘要
目的:探讨可降解高分子生物材料的性能特点及其在整形外科术后防粘连中的应用。方法:由第一作者应用万方数据库(http://www.wanfangdata.com.cn/)检索1999-01/2009-12时限内与可降解高分子生物材料在整形外科术后防粘连的应用有关的文献,关键词为"透明质酸钠及其衍生物;纤维素衍生物;医用几丁糖;聚乳酸及其共聚物;整形外科;防粘连;生物材料"。排除重复研究、综述或Meta分析类文章。结果:依据纳入排除标准共保留文献21篇。可降解高分子生物材料均具有较好的生物相容性、可降解性及可吸收性。透明质酸钠可抑制出血并具有抗炎特性。明质酸钠衍生物可弥补透明质酸钠在组织中易被降解和扩散、体内存留时间较短等缺点。羧甲基纤维素热稳定性、组织黏附性高,易于操作。氧化再生纤维素黏附性强,不需缝合;但用易受血液干扰。医用几丁糖具有一定止血功能,免疫抗原性小、无毒性。聚乳酸及其共聚物机械性能、化学稳定性优良,是最有发展前途的可生物降解的高分子材料。从应用研究的结果来看,透明质酸钠及其衍生物、纤维素衍生物、医用几丁糖和聚乳酸及其共聚物均能有效防止整形外科中术后粘连,具备广阔的发展前景。结论:可降解高分子生物材料性能优越,能有效防止整形外科中的术后粘连,具有临床应用的可能性与可行性。
OBJECTIVE：To investigate the performance characteristics of degradable polymer biomaterials and their application in the anti-adhesion after plastic surgery.METHODS：The first author retrieved Wanfang database （http：//www.wanfangdata.com.cn/） from January 1999 to December 2009 for the articles about degradable polymer biomaterials in the prevention of adhesion after plastic surgery,using Key words of ＂hyaluronic acid and its derivatives;cellulose derivatives;chitosan;polylactic acid and its copolymers;plastic surgery;anti-adhesion;biological materials＂ in Chinese.Repeated study,review or Meta analysis articles were excluded.RESULTS：According to inclusion and exclusion criteria,21 articles were involved in the analysis.Degradable polymer biomaterials have good biocompatibility,biodegradability and absorbability.Hyaluronic acid can inhibit bleeding and has anti-inflammatory properties.Hyaluronic acid derivatives can make up for the shortcomings of hyaluronic acid such as vulnerability to degradation and diffusion,as well as short lifetime in vivo.Carboxymethyl cellulose has high thermal stability and high tissue adhesion,easy to operate.Oxidized regenerated cellulose is strongly adherent,requires no suture,but is prone to interference with blood.Chitosan has a hemostatic function,immunogenicity is small,non-toxic.Mechanical properties and chemical stability of polylactic acid and its copolymers are good,thus considered as the most promising biodegradable polymers.From the application view,hyaluronic acid and its derivatives,cellulose derivatives,chitosan,polylactic acid and its copolymers can effectively prevent postoperative adhesions of plastic surgery,indicating broad prospects for development.CONCLUSION：Degradable polymer biomaterials have superior performances,effectively prevent postoperative adhesions of plastic surgery,with the possibility of clinical application.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第38期7157-7160,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
