摘要
目的研究阿米替林聚氰基丙烯酸正丁酯纳米粒(AMI-PBCA-NP)对卒中后抑郁(PSD)大鼠的疗效。方法 32只PSD大鼠随即分为4组:对照组、阿米替林(AMI)组、舍曲林组和AMI-PBCA-NP组,分别腹腔注射生理盐水、AMI水溶液、舍曲林水溶液、AMI-PBCA-NP乳液对PSD大鼠进行14d治疗,观察治疗前后大鼠体重、糖水实验、敞箱实验、多导睡眠图等变化。结果①AMI-PBCA-NP组大鼠在蔗糖水饮用量上增多,较对照组、AMI组和舍曲林组,差异有显著性(P<0.05);②AMI-PBCA-NP组大鼠Open-Field水平运动次数、垂直运动次数增多,较对照组、AMI组和舍曲林组差异有显著性(P<0.05);③AMI-PBCA-NP组大鼠多导睡眠图测定在快眼动睡眠(REM)时间和潜伏期增多,较对照组、AMI组和舍曲林组差异有显著性(P<0.05)。结论 AMI-PBCA-NP治疗PSD大鼠疗效较AMI、舍曲林显著。
ObjectiveTo study the curative effect of AMI-PBCA-NP on post-shock depression（PSD） in rats.MethodsThirty-two PSD rats were randomly assigned to control group,AMI group,sertraline group and AMIPBCA-NP group.And they were treated by intraperitoneal injection of saline,AMI,sertraline and AMI-PBCA-NP respectively for about 14 days.Then the changes in weight,sucrose solution consumption test,open-field test and polysomnogram were investigated.Results①Compared with control group,sucrose solution consumption increased in AMI,sertraline group and AMI-PBCA-NP groups.The differences were significant（P 0.05）.②Compared with control group,both horizontal and vertical movement increased in AMI,sertraline group and AMI-PBCA-NP groups.The differences were significant（P 0.05）.③Compared with control group,REM time,REM latency increased in AMI,sertraline group and AMI-PBCA-NP groups.The differences were significant（P 0.05）.ConclusionThe efficacy of AMI-PBCA-NP therapy for PSD is better than that of AMI and sertraline.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第17期2604-2606,2611,共4页
China Journal of Modern Medicine
基金
河南省医学科技攻关重点项目(No:200902008)
河南省医学科技攻关项目(No:200803082)
