摘要
目的:探讨消化道恶性肿瘤患者外周血CD4+CD25+调节性T细胞(Regulatory T cell,Treg)水平的特点及其临床意义。方法:采用流式细胞术对60例消化道恶性肿瘤患者与30名健康体检者的外周血CD4+CD25+Treg水平进行检测。结果:消化道恶性肿瘤外周血CD4+ CD25+ Treg占总T细胞7.16%±3.37%,与对照组CD4+ CD25+ Treg4.52%±1.76%比较有显著性差异(P<0.05)。结论:恶性肿瘤患者外周血CD4+CD25+Treg水平的升高,与恶性肿瘤免疫功能低下及肿瘤的发生、发展密切相关。
Objective To study the proportion of peripheral blood CD4^＋ CD25^＋ regulatory T cells in patients with gastrointestinal and hepatic cancer.Methods CD4^＋ CD25^＋ Treg cells in peripheral blood were determined with flow cytometry in 60 patients with various kinds of carcinoma （esophageal,n =18 gastric n =17 colonic n =15 hepatic n =10） and 30 controls.Results The proportion of CD4^＋ CD25^＋ in the peripheral blood of cancer patients was significantly higher than that in the controls.Conclusion The relative increase in CD4^＋ CD25^＋ regulatory T cells may give rise to immunosupression and tumor progression in patients with malignancies.
出处
《放射免疫学杂志》
CAS
2010年第5期553-555,共3页
Journal of Radioimmanology
