期刊文献+

EZH2基因在甲状腺乳头状癌组织表达及临床意义

Expression and clinical significance of EZH2 in human thyroid carcinoma
下载PDF
导出
摘要 目的研究EZH2基因在甲状腺肿瘤组织中的表达及意义。方法应用免疫组化SP法和RT-PCR方法对50例甲状腺癌和20例甲状腺瘤组织进行EZH2检测。结果 EZH2蛋白和mRNA在甲状腺癌的阳性表达率高于甲状腺瘤组织(P<0.05);发生转移的甲状腺癌组织EZH2表达高于未转移组(P<0.05)。结论 EZH2基因可能参与甲状腺癌的发生和发展,作为辅助诊断有助于良恶性甲状腺肿瘤的诊断和监测。 Objective To investigate the expression of EZH2 gene in thyroid carcinoma and its correlation with the clinicopathologic features. Methods Immunohistochemistry and RT-PCR were used to detect the expression of EZH2 in 50 thyroid carcinoma specimens and 20 thyroid adenoma specimens. Results The positivity rates of EZH2 protein and mRNA in cancer specimens were significantly higher than those in adenoma specimens (48% vs 20% ;56% vs 25% ). There was a significant difference in the expression of EZH2 between the two groups ( P 〈 0. 05 ). There was a significant relationship between EZH2 protein expression and lymphnode metastasis in thyroid cancer ( P 〈 0.05 ). Conclusion EZH2 gene is probably involved in the occurrence and development of thyroid cancer and may serve as assistant diagnosis for the determination of the biological behavior of the tumor.
出处 《河北医药》 CAS 2010年第20期2820-2822,共3页 Hebei Medical Journal
关键词 甲状腺癌 EZH2 增殖 thyroid carcinoma EZH2 proliferation
  • 引文网络
  • 相关文献

参考文献9

  • 1Ingeborg M, Bachmann OJ, Halvorsen KC, et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol,2006 ,24 :268-273. 被引量:1
  • 2Jacobs JJ,van Lohuizcn M. Polycomb repression:from cellular prolifeation and cancer. Biochim Biophys Acta,2002,1602:151. 被引量:1
  • 3Cao R,Wang L,Wang H,et al. Role of histone H3 lysine 27 methylation in polycoreb-group silencing. Science,2002,298 : 1043. 被引量:1
  • 4Plath Kathrin, Fang J, Mlynarczyk-Evans SK, et al. Role of histone H3 lysine 27 methylation in X inactivation. Science,2003,300 : ! 31. 被引量:1
  • 5Raaphorst FM, van Kemenade FJ, Blokijl T, et al. Expression of BMI1 and EZH2 polycomb group genes in reedsternberg cells of Hodgkins disease. Am J Pathol,2000 ,157 :709-712. 被引量:1
  • 6Raaphorst FM,Meijer C J, Fieret E,et al. Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene. Neoplasia, 2003,5:481-488. 被引量:1
  • 7Varambally S, Dhanasekaran SM, Zhou M, et al. The polycomb group protein EZH2 is involved in progression prostate cancer. Nature,2002,419: 624-629. 被引量:1
  • 8Bracken AP,Pasini D, Capra M,et al. EZH2 is downstream of the pRBE2F pathway,essential for proliferation and amplified in cancer. EMBO J,2003,22 : 5323-5335. 被引量:1
  • 9Ru Cao, Yi Zhang. The functions of E (Z)/EZH2-mediated methylation of lysine 27 in histone H3. Current Opinion in Genetics & Development, 2004,14 : 155-164. 被引量:1
;
使用帮助 返回顶部