期刊文献+

冠心病患者血清新碟呤水平与冠状动脉病变程度及炎症状态的关系 被引量:2

下载PDF
导出
摘要 目的探讨不同程度冠心病患者血清新蝶呤水平与冠状动脉病变程度及炎症状态的临床关系。方法选择心内科住院的急性冠脉综合征(ACS)患者44例,慢性稳定性心绞痛(SAP)患者18例,另选经冠脉造影排除冠心病者18例作对照。采用酶联免疫吸附(ELISA)方法检测血清Npt、MMP-9,hs-CRP浓度用速率散射比浊法定量测定。结果 ACS组血清Npt、MMP-9、hs-CRP水平均显著高于SAP组和对照组,且血清Npt水平与冠状动脉积分以及MMP-9、hs-CRP水平均无相关关系。结论 ACS患者血清Npt、MMP-9、hs-CRP水平均显著升高,但与冠状动脉病变程度(冠状动脉积分)无密切相关,可能Npt、MMP-9和hs-CRP等血清标志物一起可作为ACS的临床诊断评价的指标,多种指标的联合检测有助于提高敏感性。
作者 傅慎文
出处 《心脑血管病防治》 2010年第5期365-367,共3页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
  • 相关文献

参考文献4

二级参考文献32

  • 1Schumacher M, Halwachs G, Tatzber F, et al. Increased neopterin in patients with chronic and acute coronary syndromes. J Am Coll Cardiol, 1997,30 : 703 -707. 被引量:1
  • 2Garcia-Moll X, Zouridakis E, Kaski JC. Increased serum neopterin:a marker of coronary artery disease activity in women. Heart,2000,83:346-350. 被引量:1
  • 3Gurfinkel EP, Scirica BM, Bozovich G, et al. Serum neopterin levels and the angiographic extent of coronary arterial narrowing in unstable angina pectoris and in non-Q-wave acute myocardial infarction. Am J Cardiol, 1999,83:515-518. 被引量:1
  • 4Moreno PR, Falk E, Palacios IF, et al. Macrophage infiltration in acute coronary syndromes: implications for plaque. Circulation. 1994, 90:775. 被引量:1
  • 5Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993, 362:801. 被引量:1
  • 6Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med.1999,340:115. 被引量:1
  • 7Andert SE, Greismacher A, Zuckerman A, Muller MM. Neopterin release from human endothelial cells is triggered by interferon gamma.JIFCC. 1995, 7:70. 被引量:1
  • 8Berk BC, Weintraub WS, Alexander RW. Elevation of C - reactive protein in ""active"" coronary artery disease. Am J Cardiol. 1990, 65:168. 被引量:1
  • 9Schumacher M, Halwachs G, Tatzber F, et al. Increased neopterin in patients with chronic and aucte coronary syndromes. J Am Coll Cardiol. 1997, 30:703. 被引量:1
  • 10Berliner JA, Territo MC, Sevanian A, et al. Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest. 1990,85:1260. 被引量:1

共引文献33

同被引文献18

  • 1程致,谭明灯,张德权.急性冠状动脉综合征患者血清高敏C反应蛋白和新蝶呤的检测及意义[J].中国基层医药,2006,13(2):235-236. 被引量:7
  • 2赵成军,贾如意,姜婕,柳翠霞,虞化鹏,王涛,殷洁.外周动脉粥样硬化预测非心肌梗死冠心病多支病变的价值[J].中国医师进修杂志(内科版),2007,30(4):29-31. 被引量:1
  • 3徐荣丰,高大胜,王红雷.血清新蝶呤和单核细胞趋化蛋白-1在冠心病患者血清中的表达及意义[J].中国心血管病研究,2007,5(6):420-422. 被引量:13
  • 4Alber HF,Duftner C,Wanitschek M,et al. Neopterin, CD4+ CDa-lymphocytes and the extent and severity of coronary artery disease.Int J Cardiol,2009,135( 1 ):27-35. 被引量:1
  • 5Urbano Moral JA, Lopez Haldon JE, Fernandez M, et al. Prognostic value of different serum biomarkers for left ven- tricular remodelling after ST-elevation myocardial infarction treated with primary percutaneous coronary intervention [J]. Heart, 2012, 98(15): 1 153-159. 被引量:1
  • 6Frangogiannis NG. The inflammatory response in myocardi- al injury, repair, and remodeling [J]. Nat Rev Cardiol, 2014, 11(5) : 255-265. 被引量:1
  • 7Craig DG, Lee P, Pryde EA, et al. Serum neopterin and soluble CD163 as markers of macrophage activation in paracetamol (acetaminophen)-induced human acute liver injury[J]. Aliment Pharmacol Ther, 2013, 38(11-12): 1 395 -404. 被引量:1
  • 8Levine GN, Bates ER, Blankenship JC, et al. 2011 AC- CF/AHA/SCAI guideline for percutaneous coronary inter- vention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular An- giography and Interventions [J]. Catheter Cardiovasc In- terv, 2013, 82(4): 266-355. 被引量:1
  • 9Savoye C, Equine O, Tricot O, et al. Left ventricular re- modeling alter anterior wall acute myocardial infarction in modem clinical practice (from the Remodelage Ventricu- laire [REVE] study group) [J]. Am J Cardiol, 2006, 98 (9): 1 144-149. 被引量:1
  • 10Dominguez-Rodriguez A, Abreu-Gonzalez P, Avanzas P. Relation of growth-differentiation factor 15 to left ventrieular remodeling in ST-segment elevation myocardial infarction [J]. AmJCardiol, 2011, 108(7): 955-958. 被引量:1

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部