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Evaluation of non-typical diffuse axonal injury by magnetic resonance techniques 被引量:3

Evaluation of non-typical diffuse axonal injury by magnetic resonance techniques
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摘要 Because diffuse axonal injury(DAI)lacks specific clinical manifestations,it is difficult to evaluate DAI using computer tomography or conventional magnetic resonance imaging(MRI).This study investigated the value of magnetic resonance techniques using fluid-attenuated inversion recovery(FLAIR)and proton magnetic resonance spectroscopy(1HMRS)for diagnosing DAI.The corpus callosum and basal nuclei were analyzed using morphological and functional imaging.Similar to the DAI group,the non-typical DAI group exhibited similar lesion characteristics on FLAIR,as well as post-injury neurochemical and molecular changes in the corpus callosum,as detected by 1HMRS.However,there were differences in degree and severity of injury.Compared to conventional MRI,FLAIR significantly increased lesion detection.1HMRS determined biochemical metabolism changes in midline structures following DAI,which resulted in increased diagnosis of non-typical DAI,which displayed similar lesion distribution,morphology,and function as DAI.Thus,the experiment proved the value of FLAIR and 1HMRS in non-typical DAI. Because diffuse axonal injury(DAI)lacks specific clinical manifestations,it is difficult to evaluate DAI using computer tomography or conventional magnetic resonance imaging(MRI).This study investigated the value of magnetic resonance techniques using fluid-attenuated inversion recovery(FLAIR)and proton magnetic resonance spectroscopy(1HMRS)for diagnosing DAI.The corpus callosum and basal nuclei were analyzed using morphological and functional imaging.Similar to the DAI group,the non-typical DAI group exhibited similar lesion characteristics on FLAIR,as well as post-injury neurochemical and molecular changes in the corpus callosum,as detected by 1HMRS.However,there were differences in degree and severity of injury.Compared to conventional MRI,FLAIR significantly increased lesion detection.1HMRS determined biochemical metabolism changes in midline structures following DAI,which resulted in increased diagnosis of non-typical DAI,which displayed similar lesion distribution,morphology,and function as DAI.Thus,the experiment proved the value of FLAIR and 1HMRS in non-typical DAI.
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第17期1337-1341,共5页 中国神经再生研究(英文版)
基金 the Grant from Chongqing Board of Health, No. 2009-2-391, No. 06-2-175 the Grant from Chongqing Medical University, No. XBYB2007005
关键词 diffuse axonal injury magnetic resonance imaging magnetic resonance spectroscopy case-control study traumatic brain injury diffuse axonal injury magnetic resonance imaging magnetic resonance spectroscopy case-control study traumatic brain injury
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