摘要
目的探讨术中植入缓释氟尿嘧啶预防胃癌术后复发的临床效果。方法选择胃癌患者60例,按随机数字表法分成对照组30例和治疗组30例。所有患者均行胃癌根治术,其中近端胃切除术28例,远端胃切除术22例,全胃切除术10例,治疗组在手术基础上另加腹腔植入缓释氟尿嘧啶。随访观察患者术后复发情况。结果胃癌术后复发与性别、年龄无明显关系(P>0.05),胃癌患者手术方式、切缘情况、肿瘤分化程度、TNM分期则直接影响到肿瘤的复发时间(P<0.05)。治疗组术后复发时间[(20.6±4.0)个月]明显较对照组[(16.7±5.0)个月)延长(P<0.05)。2组术后在不同时期内局部复发率治疗组明显低于对照组(均P<0.05)。结论胃癌根治术中植入缓释氟尿嘧啶可有效地降低胃癌术后复发率,减少术后复发及转移的发生,实现治愈胃癌的目的 。
Objective To investigate the clinical effects of fluorouracil sustained-release implants during operation in prevention of gastric cancer recurrence.Methods Sixty selected patients with gastric cancer were randomly divided into control group and treatment group（30 patients in each group）,and all patients underwent radical gastrectomy.Of the 60 patients,proximal gastrectomy was performed in 28,distal gastrectomy in 22,total gastrectomy in 10.The patients in treatment group were intraperitoneally implanted with sustained-release fluorouracil.All patients were followed up to observe tumor recurrence,cancer metastasis and patient survival.Results Gastric cancer recurrence was not significantly correlated with gender and age（P〈0.05）.Surgical procedures,margin status,tumor differentiation and TNM staging had a direct impact on recurrence time（P〈0.05）.The recurrence time in treatment group [（20.6±4.0）months] was significantly longer than that in control group[（16.7±5.0）months]（P〈0.05）.The local recurrence rate in different periods in treatment group was obviously lower than that in control group（all P〈0.05）.Conclusion Fluorouracil sustained-release implants during gastrectomy can effectively reduce the incidence of recurrence and metastasis to achieve the purpose of cure.
出处
《实用临床医学（江西）》
CAS
2010年第10期51-53,共3页
Practical Clinical Medicine
关键词
胃癌
胃癌根治术
缓释氟尿嘧啶
植入
预防
复发
gastric cancer
radical gastrectomy
sustained-release fluorouracil
implant
prevention
recurrence
