摘要
从一株深海沉积物来源真菌Phialocephala sp.中分离得到了一个新的倍半萜对苯二酚(1)。结合波谱学数据以及旋光性确定了它的平面和立体结构。化合物1对小鼠白血病细胞P388和人白血病细胞K562均显示了很强的增殖抑制活性,其IC50值分别为0.16和0.05μmol·L-1。
A new sesquiterpene hydroquinone （I） was isolated from a deep sea sediment derived fungus, Phialocephala sp.. Its structure and stereochemistry were established on the basis of spectroscopic data and optical rotation. This compound was tested for cytotoxicity against P388 （murine leukemia cell） and K562 （human leukemia cell） cell lines, and displayed strong cytotoxic effects with IC50 value of 0.16 and 0.05 μmol·L^-1, separately.
出处
《药学学报》
CAS
CSCD
北大核心
2010年第10期1275-1278,共4页
Acta Pharmaceutica Sinica
基金
Project supported by the National Science Foundation of China (30772640)
关键词
倍半萜对苯二酚
真菌次级代谢物
细胞毒活性
sesquiterpene hydroquinone
fungal secondary metabolite
cytotoxic activity
