摘要
从云南萝芙木(Rauvolfia yunnanensis Tsiang)花乙酸乙酯提取物中分离得到9个化合物(其中4个为吲哚类生物碱),即(18Z)-11-Methoxypicrinine(1),Caberoline(2),11-Methoxystrictamine(3)和Strictamine(4),以及Russulamide(5),Ursolic acid(6),Urs-12(13)-en-3α-yl acetate(7),β-Amyryl nonanoate(8)和β-Sitosterol(9);采用UV,IR,MS和1D,2D NMR方法对化合物的结构进行了鉴定,其中化合物1为新吲哚生物碱,化合物5,7和8系首次从该植物中分离得到,但未得到利血平和育亨宾.
Rauvolfia yunnanensis Tsiang are commonly used as a folklore herb to treat hypertension,snake bites,and insanity in the southwest of China,and an important industrial raw material of reserpine.The phytochemical constituents of the rhizome of it have been investigated intensively.Reserpine and yohimbine are two effective biological activities compounds isolated from the rhizome of Rauvolfia yunnanensis.But the wild resources of it reduced gradually in recent years,thus we have introduced and cultivated it to the arid hot valley region of Yunnan,China,and investigated the chemical constituents variety of it for the sustainable utilization.In the present work,the chemical constituents of the flowers of R.yunnanensis have been investigated for extending the utilizable efficiency of resources.The dried flowers powder（1.0 kg） of R.yunnanensis was extracted with 95% EtOH（10 L × 6,48 h each） at room temperature,and then extracted successively with EtOAc（1 L × 6）.The EtOAc portion（50 g） led to the isolation of nine compounds by column chromatography（silica,alumina and Sephadex LH-20 gel） methods.Their structures were identified as（18Z）-11-methoxypicrinine（1）,caberoline（2）,11-methoxystrictamine（3）,strictamine（4）,russulamide（5）,ursolic acid（6）,urs-12（13）-en-3α-yl acetate（7）,β-amyryl nonanoate（8） and β-sitosterol（9） by spectral analysis（UV,IR,MS and 1D,2D NMR）,respectively.Among them,compound 1 is a new indole alkaloids,compounds 5,7 and 8 are firstly isolated from it.But reserpine and yohimbine haven＇t been isolated.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2010年第10期2005-2009,共5页
Chemical Journal of Chinese Universities
基金
云南省自然科学基金(批准号:2005B0049M)资助
