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代谢综合征合并肥胖相关性肾病临床病理特征分析 被引量:9

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摘要 目的分析代谢综合征(MS)合并肥胖相关性肾病(ORG)患者的临床表现、实验室检查结果及肾活检组织病理学改变。方法回顾性分析MS并ORG(n=27)或不合并ORG(n=30)患者的临床病理资料。ORG根据肾活检组织学改变分为肥胖相关性单纯性肾小球肥大(O-GM,n=15)组和肥胖相关性局灶节段性肾小球硬化(O-FSGS,n=12)组。结果 MS-ORG组与MS对照组,以及O-GM亚组与O-FSGS亚组,在高血压、空腹血糖异常、血脂紊乱方面的发生率的均无统计学差异(P>0.05)。O-FSGS组的24h尿蛋白定量(g)显著高于O-GM组(3.07±2.28vs2.22±1.50,P=0.025)。肾小球肥大是MS-ORG的共同特征。O-FSGS组的球性肾小球硬化比例显著高于O-GM组(9.13±4.01vs4.67±2.04,P=0.000),而小动脉病变的发生频率则显著低于O-GM组(P=0.030)。结论 MS-ORG与MS对照组无临床特征差异,而O-FSGS与O-GM有不同的临床病理特征。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第19期2749-2751,共3页 Chinese Journal of Gerontology
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参考文献7

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