摘要
目的：了解锌对尿毒症血透患者血细胞血清睾丸酮水平及免疫功能的影响。方法：给６０例尿毒症缺锌血透患者口服葡萄糖酸锌１００ｍｇ／ｄ，持续３～４个月，观察补锌前后嗜中性粒细胞，血红蛋白，血小板，血清睾丸酮水平及Ｔ淋巴细胞亚群百分比的含量情况。结果：补锌后尿毒症血透患者的血清锌，嗜中性粒细胞，血清睾丸酮水平，Ｔ淋巴细胞亚群百分比ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８较补锌前明显增高，差异显著（Ｐ＜００５）。补锌前后的血清锌与嗜中性粒细胞、血清睾丸酮水平、ＣＤ３呈正相关。结论：口服葡萄糖酸锌能改善尿毒症缺锌患者嗜中性粒细胞、血清睾丸酮水平及免疫功能，减轻临床症状。
OBJECTIVE ToinvestigatethechangesofimmunologicalstatusofhemodialysispatientsaftertheadministrationofGluconasZinc. METHODOLOGY Thisstudyincluded60patientsonmaintenancehemodialysisforatleastthreemonths.GluconasZinewasadministraedat100 mg/dayfor3months.SerumzincwasdeterminedwithAtomicAbsorbentSpectrophotometer.Peripheralneutrophilicgranulocyte(GR),CD3+,CD4+,CD8+lymphocytecountsandserumtestosteronewereinvestigatedbeforeandaftertheadministrationofGluconasZinc. RESULTS Asignificantdecrementofserumzinclevelwasfoundinhemodialysispatientsbeforetreatmentascomparedtonormalcontrols(976184vs1632164,P<005).AndasignificantincrementofserumzinclevelwasobservedaftertheadministrationofGluconasZinc(976184vs1334215,P<005).Significantincrementsofserumtestosteronelevel,GRcounts,CD3+,CD4+lymphocytecountsandtheratioofCD4/CD8wereobservedaftertreatmentwithGluconasZinc.Correlationanalysisrevealedthatserumtestosteronelevel,GRcounts,CD3+lymphocytecountswerepositivelycorrelatedwiththelevelofserumzinc. CONCLUSION Administr
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1999年第3期236-237,共2页
Chinese Journal of Nephrology,Dialysis & Transplantation
关键词
葡萄糖酸锌
慢性
免疫
血液透析
睾酮
尿毒症
zincimmunefunctionhemodialysisationofzincisveryimportanttohemodialysispatientslackingforzincwithrespecttotheimprovmentoftheimmunestatus.
