摘要
阿尔茨海默病(AD)是老年人常见的神经系统变性疾病。越来越多的证据表明,β淀粉样蛋白(Aβ)是AD的共同通路,是AD形成和发展的关键因素,是构成老年斑(SP)的主要成分。目前在分子生物学迅速发展的基础上开始形成了一种新的疗法——基因免疫法:通过基因编码的蛋白在动物自身细胞中表达,从而诱发免疫反应,以对抗与疾病有关的特异蛋白的方法。目前通过动物模型和人体试验表明,基因疫苗可减少或清除Aβ。本文结合文献对疫苗的免疫机制及主动免疫、被动免疫治疗进行概述。
Alzheimer＇s disease （AD） is a common neurodegenerative disorder in aged humans. More and more evidence indicates that amyloid-β protein （Aβ） ,which is the major component of senile plague,plays critical roles in the onset and progression of AD. Rapid developments in molecular biology enable a new therapy strate- gy--DNA vaccine therapy. Genetic immunization： It＇s the method that the expression of the proteins encoded by genes in the animal＇s own cells induces immune response to combat the disease related specific proteins. It has been demonstrated in animal models and human clinical trials that DNA vaccine is effective in reducing and eliminating the Aβ burden. Combined literatures, this article summarized as follows on immune mechanism, active and passive immunotherapy of vaccine.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2010年第10期936-938,共3页
Chinese Journal of Practical Internal Medicine
基金
国家自然科学基金(30471927)
关键词
阿尔茨海默病
Β淀粉样蛋白
免疫治疗
主动免疫
被动免疫
Alzheimer＇s disease
amyloid-beta protein
immunotherapy
active immunity
passtive immunity
