摘要
目的：制备硝苯地平缓释片并测定释放度和犬血药浓度。方法：采用固体分散法制备硝苯地平固体分散，再加入阻滞剂制得缓释片。以５％乙醇为释放介质，５０ｒ·ｍｉｎ－１，浆法，测定释放度。用ＨＰＬＣ法测定犬口服缓释片后的血药浓度。结果：硝苯地平缓释片与对照品拜心通３０１２ｈ累计释药分别为６８．３％和６４．１％。犬口服硝苯地平缓释片后可维持有效血药浓度达２０ｈ。结论：采用固体分散加阻滞剂的方法制得的缓释片具有明显的缓释效果。本品对温度和湿度较稳定，对光不稳定。
OBJECTIVE :To prepare the long acting nifedipine tablet,determined dissolution rate and plasma concentration of nifedipine in dog. METHODS :The tablet was prepared with solid dispersion method.Dissolution testing was performed in 5% alcohol solution paddle method 50 rmin-1. Plasma contentration was analysed with HPLC. RESULTS :12h release of the long acting tablet and adalat GITS 30 was 68.3% and 64.1% respectively.Effective concentration of nifedipine was kept up to 20h. CONCLUSIONS :The balet is a sustained release tablet,it is stable for 10 days at 60,for 90 days at 40 RH 75%.unstable under the sun light.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1999年第5期267-269,共3页
Chinese Journal of Hospital Pharmacy
关键词
硝苯地平
长效缓释片
释放度
血药浓度
nifedipine,long acting release,tablet dissolution rate,plasma concentration
