摘要
目的:观察缬沙坦联合维生素E对糖尿病肾病的治疗作用。方法:将确诊为糖尿病肾病的80例患者随机分为两组,治疗组41例在常规糖尿病治疗的同时给予缬沙坦80mg/d,加用口服维生素E0.1g/d;对照组39例在常规糖尿病治疗的同时单用缬沙坦80mg/d,两组均以3个月为1个疗程。观察两组治疗前后的24hUAER、BUN、SCr等指标的变化。结果:治疗3个月后两组UAER与治疗前相比均显著下降(P<0.05或P<0.01),治疗后治疗组UAER较对照组显著下降(P<0.05),而BUN、SCr等指标与治疗前相比均无显著性差异(P>0.05)。结论:缬沙坦联合维生素E治疗糖尿病肾病在减少尿白蛋白方面有协同作用,两药合用的疗效比单用缬沙坦好。
Objective： To observe the clinical efficacy of combination of Valsartan and Vitamin E on treating diabetic nephropathy. Methods： 80 patients with diabetic nephropathy were randomly divided into two groups, treatment group （n= 41） and control group （n=39）, they were routinely treated with general treatment for diabetic. The treatment group was given 80 mg Valsartan daily, plus 0.1 g Vitamin E daily; the control group was given 80 mg Valsartan daily alone. 3 months courses of treatment, the observed indicators were 24 h urinary albumin eliminate rate, blood urea nitrogen, serum creatine and so on the indicators change were compared in two groups. Results： There was a decrease of 24 h UAER after 3 months of treatment in two groups （P0.05, P0.01）, more significant in treatment group compared to that of control groups （P0.05）, blood urea nitrogen and serum creatine didn′t show statistical difference between two groups （P0.05）. Conclusion： The combination of Valsartan and Vitamin E is effective in the therapy of diabetic nephropathy, which can decrease urinary albumin, it is superior to Valsatan alone.
出处
《中国医药导报》
CAS
2010年第28期32-33,共2页
China Medical Herald
关键词
糖尿病肾病
缬沙坦
维生素E
尿蛋白
Diabetic nephropathy
Valsartan
Vitamin E
Urinary albumin
