摘要
近年来新作用机制的复方抗高血压药物不断涌现,其研发和临床应用逐渐增加。新型复方抗高血压药物能够增强降压疗效和/或减少不良反应,并使患者的服药依从性得到明显改善。因此,新型复方抗高血压药物的前景受到重视,开始成为复方降压药的主流。本文对我国复方抗高血压药物的发展趋势进行了分析探讨,提出应有更多的大规模临床试验进一步充实新型复方降压药的循证医学证据。由于复方抗高血压药物的临床地位趋于上升,随着降压治疗观念的转变,采用优化的初始联合用药或者复方制剂治疗可能成为新的趋势。
Combination drugs of new mechanisms are constantly emerging,and the development and clinical application of these drugs have been significantly increased.New combination antihypertensive drugs can markedly improve compliance and antihypertensive efficacy as well as reduce adverse events.Therefore,new-mechanism antihypertensive drug combinations are becoming a mainstream of the combination therapies.This article described trends in the development of new-mechanism antihypertensive drug combinations in China.More large-scale clinical trials will enrich the medicine evidence of combination therapies.With the transformation of therapy conception,it is probable that optimized initial combination therapies may become a new prevalence.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2010年第18期1652-1656,共5页
Chinese Journal of New Drugs
关键词
高血压
复方抗高血压药物
发展趋势
hypertension
combination antihypertensive drugs
development trend
