摘要
目的：了解原发性高血压（ＥＨ）细胞外间质成分的变化及与左室肥厚（ＬＶＨ）的关系。方法：采用心脏超声多普勒技术及放免技术测定３３例ＥＨ伴ＬＶＨ、３６例ＥＨ不伴ＬＶＨ及２０例正常人左室重量指数（ＬＶＭＩ）及血清Ⅲ、Ⅳ型前胶原神经末端肽（ＰⅢＰ、ＰⅣＰ）及透明质酸（ＨＡ）。结果：ＥＨ患者ＰⅢＰ、ＰⅣＰ、ＨＡ含量均高于正常人，ＰⅢＰ／ＰⅣＰ比值也出现改变，而且ＬＶＨ者和非ＬＶＨ者相比，差异显著，ＰⅢＰ、ＰⅣＰ、ＨＡ和ＬＶＭＩ呈正相关。结论：ＥＨ时细胞外间质出现异常增生，比例失调可能参与ＬＶＨ形成。
Objective: To investigate the changes of serum procollagen type (PP),procollagen type
(PP),hyaluronic acid (HA) in essential hypertensives (EH) and their relation with left ventricular
hypertrophy (LVH). Method: PP,PP,HA were measured by radioimmunoassay in 33 EH patients
with LVH,36 EH without LVH and 20 healthy subjects. Result: Serum PP,PP, HA were
significantly increased in hypertensive patients with LVH as compared with those without LVH
and healthy subjects. Serum PP, PP ,HA positively correlated with left ventricular mass index in
those with hypertension. Conclusion: The extracellular matrix coponents in the EH were
significantly increased with abnormal ratio betwen then possibly involved in the genesis of left
ventricular hypertrophy.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1999年第6期243-245,共3页
Journal of Clinical Cardiology
关键词
高血压
左心室肥厚
胶原
透明质酸
浓度
HypertensionLeft ventricular
hypertrophyCollagenHyaluronic acid
