摘要
免疫组化SABC法检测42例原发性胃癌切除标本E－cadherin的表达，结果阳性表达占333％，阴性表达占66．7％；E－cadherin表达与胃癌大体类型、淋巴结转移、组织学分型等临床病理因素有关（P＜005），而与肿瘤直径、Borrmann分型无关（P＞0．05）。此外，不同的病理分期之间E－cadherin表达差异显著（P＜0．05）。表明E-cadherin在胃癌中的表达可作为预测其生物学行为及预后的指标。
The expression of E-cadherin was irnmunohistochemically analyzed (SABC method) in 42 cases of human primarygastnc carcinomas which were all sustained postoperatively. We found that the rate of positive expression was 33 .3 % (14cases), the negative rate was 66. 7 % (28 cases). By statistical study, we concluded that the expression of E - cadherinwas associated with the macroscopic trpe, Iymph node metastasis and histologic type in gastric carcinoma (P < 0. 05 ),but have no relation with the tumor size, Borrmann type (P > 0 .05 ). Furthermore, the expression of E - cadherin in def-ferent clinicopathologic stages also differed significantly. These results indicate that the expression of E - cadherin in gas-tric carcinorna mav well be looked as a new varible used to asses its biological behaviour and its prognostic value need tobe further studied.
出处
《苏州医学院学报》
1999年第6期622-623,共2页
Acta Academiae Medicinae Suzhou
关键词
E-CADHERIN
胃肿瘤
免疫组织化学
E-cadherin
immunohistochemistry
gastric carcinoma
biological behaviou
