摘要
目的:观察氟比洛芬酯与双异丙酚-力蒙欣配伍用于人工流产手术中及术后的镇痛效果,并评估不同剂量的氟比洛芬酯复合同等剂量的双异丙酚-力蒙欣的镇痛效果及安全性,探讨氟比洛芬酯安全有效的单次术前最佳给药剂量。方法:选择美国麻醉师协会分级Ⅰ～Ⅱ级的自愿要求行无痛人工流产患者60例,随机均分为3组,I组双异丙酚-力蒙欣复合氟比洛芬酯1.0mg/kg,II组双异丙酚-力蒙欣复合氟比洛芬酯1.5mg/kg,Ⅲ组为双异丙酚-力蒙欣组,双异丙酚-力蒙欣诱导剂量为2mg/kg,静注速率均为100mg/min。观察并纪录三组用药前、术中、术毕清醒时平均动脉压(MAP)、心率(HR)、呼吸频率(RR)及脉搏血氧饱和度(SPO2);诱导时间和苏醒时间;双异丙酚-力蒙欣注射痛发生的例数双异丙酚-力蒙欣用药量:双异丙酚-力蒙欣总用药量与患者体重之比(mg/kg);麻醉期间的不良反应,包括体动、苏醒期躁动、术后恶心呕吐发生的例数;术中麻醉效果以及术毕清醒后1、15、30、45、60min宫缩痛视觉模拟评分(VAS)值。结果显示,三组受术者年龄、体重、手术时间、术中补液比较力蒙欣用量、意识消失时间差异无统计学意义(P>0.05);但意识清醒时间I组明显少于另外两组(P<0.05),II组少于III组,但差异无统计学意义(P>0.05);与术前相比,三组患者术MAP及SpO2均降低(P<0.05);Ⅲ组患者术中HR较术前均降低(P<0.05)。相同时刻组间比较,Ⅱ组患者在三个时点均低于其他两组(P<0.05),Ⅲ组患者术中心率低于I组患者(P<0.05)。三组患者术毕清醒时的各项指标与术前相比无显著性差异(P>0.05)三组患者在诱导期间均有较多例数发生双异丙酚-力蒙欣注射痛,分别为17例、18例和19例,组间比较差异无统计学意义(P>0.05);术中体动、苏醒期躁动及术后恶心呕吐Ⅲ组患者明显高于其他两组(P<0.01),Ⅱ两组患者术中体动发生的次数也高于Ⅰ组(P<0.05)术毕�
Objective：To observe flurbiprofen with Propofol-Propofol Compatibility for induced abortion and post-operative analgesia and to assess different doses of the same dose of flurbiprofen complex two-propofol-Propofol analgesia and safety,of flurbiprofen safe and effective single preoperative dose.American Association of Classification.Methods：Anesthetist ⅠⅡ,voluntary induced abortion required trekking 60 patients were randomly divided into 3 groups,I set Propofol-Propofol combined with flurbiprofen axetil 1.0mg/kg,II group Propofol-Propofol combined with flurbiprofen axetil 1.5mg/kg,Ⅲ group Propofol-Propofol group,Propofol-Propofol induction dose of 2mg/kg,infusion rate were 100mg/min.Observe and record the three groups before treatment,surgery,of surgery awake mean arterial pressure （MAP）,heart rate （HR）,respiratory rate （RR） and pulse oxygen saturation （SPO2）;induction time and recovery time;two-different propofol-Propofol injection pain occurred in the number of cases Propofol-Propofol dosage：Propofol-Propofol total dosage and body weight ratio （mg/kg）;adverse reactions during anesthesia,including body movement,agitation,nausea and vomiting after the number of patients;intraoperative anesthesia and conscious of surgery 1,15,30,45,60 min contraction pain visual analogue score （VAS） value.The Results showed that three groups of patients were affected by age,weight,operative time,intraoperative fluid Propofol compared the amount of time,loss of consciousness was no significant difference （P〉 0.05）;but conscious time I was significantly less than the other two groups （P 〈0.05）,II group than III,but the difference was not significant （P〉 0.05）;compared with before surgery,three groups of patients undergoing MAP and SpO2 were lower （P 〈0.05）;Ⅲ surgery patients in HR were lower than preoperative （P 〈0.05）.The same time between the two groups,Ⅱ patients in the three time points were lower than the other two groups （P 〈0.05）,Ⅲ group I patients u
出处
《医学信息（中旬刊）》
2010年第10期2676-2679,共4页
Medical Information Operations Sciences Fascicule
