摘要
目的探讨前列地尔注射液、倍他司汀联合丹参川芎嗪注射液治疗椎-基底动脉供血不足的临床疗效。方法将86例椎-基底动脉供血不足患者按随机数字表法分为2组:联合治疗组46例和丹参川芎嗪组40例。2组患者均采用倍他司汀联合丹参川芎嗪注射液治疗。在此基础上,联合治疗组加用前列地尔注射液治疗。观察2组患者治疗前、治疗14 d后脑血流动力学指标[左侧椎动脉(LVA)和右侧椎动脉(RVA)的收缩峰流速和舒张末期流速]、纤维蛋白原水平的变化及治疗14 d后临床疗效、不良反应等情况。结果联合治疗组总有效率明显高于丹参川芎嗪组(P<0.05),联合治疗组治疗14 d后纤维蛋白原水平明显低于丹参川芎嗪组(P<0.05),联合治疗组治疗14 d后收缩峰流速LVA、收缩峰流速RVA、舒张末期流速LVA、舒张末期流速RVA血流速度均较丹参川芎嗪组增快(均P<0.05)。联合治疗组有1例出现胃肠不适,有2例出现注射部位发红、搔痒,均可忍受,不影响治疗。丹参川芎嗪组无不良反应发生。结论前列地尔注射液、倍他司汀联合丹参川芎嗪注射液治疗椎-基底动脉供血不足,能显著的扩张脑血管,改善椎动脉的血流量,增加脑血流速度;有效的降低纤维蛋白原水平,且不良反应少。
Objective To explore the clinical curative effects of combined treatment with alprostadil injection,and betahistine and salviae miltiorrhizae and ligustrazine hydrochloride injection on vertebro-basilar artery insufficient perfusion.Methods Eighty-sixth patients with vertebro-basilar artery insuffiAcient perfusion were randomly divided into 2 groups to the number table method：combined treatment group（n=46） and salviae miltiorrhizae and ligustrazine hydrochloride injection（SMLH） group（n=40）.All 86 patients were treated with betahistine and salviae miltiorrhizae and ligustrazine hydrochloride injection.On this basis,the patients in combined treatment group were treated with betahistine and salviae miltiorrhizae and ligustrazine hydrochloride injection plus alprostadil injection.Cerebral hemodynamics,including left vertebral artery（LVA） and right vertebral artery（RVA） of the peak systolic velocity and end diastolic velocity,were examined before and 14 days after treatment.The levels of fibrinogen,clinical effects and adverse reactions were observed after treatment.Results The total effective rate in combined treatment group was significantly higher than that in SMLH group（P〈0.05）,while the levels of fibrinogen in combined treatment group were significantly lower than that in SMLH group（P〈0.05）.Compared with SMLH group,The speed of blood flow in LVA and RVA of the peak systolic velocity and end diastolic velocity increased in combined treatment group after treatment（all P〈0.05）.In combined treatment group,gastrointestinal discomfort occurred in 1 patient,and injection site redness and itching in 2 patients.These symptoms could be endured and did not affect the treatment.No adverse reactions occurred in SMLH group.Conclusion The combined treatment with alprostadil injection,and betahistine and SMLH injection on vertebro-basilar artery insufficient perfusion can significantly dilate cerebral blood vessels,improve vertebral artery blood flow,increase cerebral blood flow velocity,d
出处
《实用临床医学（江西）》
CAS
2010年第9期13-15,19,共4页
Practical Clinical Medicine
关键词
椎-基底动脉供血不足
前列地尔注射液
丹参川芎嗪注射液
疗效
vertebro-basilar artery insufficient perfusion
alprostadil injection
salviae miltiorrhizae and ligustrazine hydrochloride injection
curative effect
