摘要
[目的]考察了1-苯并环庚酮的合成路线。[方法]以1-溴-3-苯基丙烷和丙二酸二乙酯为原料,通过取代反应,制得2-(3-苯丙基)丙二酸,对其加热脱羧得到中间体5-苯基正戊酸,再用多聚磷酸(PPA)环化脱水生成1-苯并环庚酮。[结果]反应总收率达52.9%～61.0%。用IR,1HNMR及MS对中间体、最终产物进行了表征。[结论]该方法操作简便,反应收率高,为1-苯并环庚酮的合成提供了一条经济路线。
[Objective] The purpose of this research was to study the synthesis of 1-benzosuberone.[Method] The cyclodehydration of 5-phenylvaleric acid prepared from 1-bromo-3-phenylpropane and diethyl malonate by substitution reaction to give 2-（3-phenylpropyl）-malonic acid which was subjected by decarboxylation with heating,with polyphosphoric acid afforded 1-benzosuberone.[Result] The overall yield was 52.9%-61.0%.Structures of the intermediates and the final product were characterized by IR,NMR and MS.[Conclusion] This method was simple,high efficiency,and provided an economical route for synthesis of 1-benzosuberone.
出处
《安徽农业科学》
CAS
北大核心
2010年第19期9948-9949,共2页
Journal of Anhui Agricultural Sciences
