摘要
乳凝集素是一种黏附在乳汁脂肪球膜表面的镶嵌型外周蛋白，在机体其他体液中也有表达，存在于多物种内，发挥多种功能：增进凋亡淋巴细胞及其他凋亡细胞的吞噬清除，促进肠黏膜的修复，增加树突状细胞外泌小体功能，促进乳腺分支的形态发生，促血管形成，调节精子与卵细胞外围的黏附等。该文主要综述乳凝集素的结构功能及其在治疗方面的应用前景。
Lactadherin is an important membrance-associated glycoprotein that detected on the surface of human milk fat globule. It has been independently identified in many species and now known to participate in a wide variety of cellular interactions, including phagocaryosis of apoptotic lymphcytes and other apoptotic cells, repairing of intestinal mucosa, facilitateing exosome-function in dendritic cells, mammary gland branching morphogenesis, angiogenesis,adhesion between sperm and the egg coat, etc. This article explores the various functions of lactadherin, as well as its therapeutic potential.
出处
《国际儿科学杂志》
2010年第5期515-517,共3页
International Journal of Pediatrics
关键词
乳凝集素
吞噬
肠黏膜修复
Lactadherin
Phagocaryosis
Repair of intestinal mucosa
