摘要
目的:探讨支气管扩张症急性感染期患者治疗前后血清瘦素(leptin)水平的变化及其临床意义。方法:测定支气管扩张症急性感染期患者治疗前后及健康对照者血清leptin、白介素(IL-8、IL-13)水平,进行比较及相关性分析。结果:支气管扩张症急性感染期患者治疗前的血清leptin、IL-8、IL-13水平高于治疗后,且均高于正常对照组,差异均有统计学意义(P<0.05);治疗前后血清leptin与IL-8、IL-13均呈正相关性。结论:血清leptin可作为支气管扩张患者急性感染期的炎症性标志物之一,其水平高低与病情的发展及预后密切相关。
Objective：To investigate the level and clinical significance of serum leptin in acute infection stage in bronchiectasis patients before and after therapy.Methods：Serum leptin,IL78 and IL-13 levels of patients with bronchiectasis before and after therapy and healthy people were measured.Results：The levels of serum leptin,IL-8 and IL-13 were significantly different in patients with bronchiectasis between before and after therapy, and were significantly different between patients with bronchiectasis and healthy people（P〈0.05）.The Positive correlation was obtained between leptin and IL-8,IL-13,regardless of before or after therapy.Conclusion：The serum leptin may be one of inflammation markers in acute infection stage in bronchiectasis patients.It＇s serum levels in patients with bronchiectasis are closely related with the development and prognosis of the disease.
出处
《中国医药导刊》
2010年第9期1486-1487,共2页
Chinese Journal of Medicinal Guide
