摘要
目的探讨原发性皮肤CD30+间变大细胞淋巴瘤(C-ALCL)的临床病理特征、免疫表型及预后,提高对C-ALCL的认识和病理诊断水平。方法对6例C-ALCL进行临床病理分析及免疫组化染色。结果 6例中男性3例,女性3例,中位年龄45岁。以皮肤结节为主要临床表现。组织学上具有间变大细胞淋巴瘤的形态特征,瘤细胞体积大,有明显的多形性和异形性,免疫组化6例瘤细胞弥漫表达CD30+,2例ALK+,3例EMA+,T细胞标记可有CD3、CD4、CD45RO或TIA-1的表达,均不表达CK、CD20、S-100、HMB45。结论 C-ALCL少见,掌握其形态学及免疫组化特点对诊断、鉴别诊断及预后具有重要意义。
Objective To investigate the clinicopathologic features,immunohistochemical findings of primary cutaneous anaplastic large cell lymphoma（C-ALCL）.Methods Six cases of C-ALCL were enrolled into the study,the clinicopathologic features,immunohistochemical findings were analyzed.Results There were 3 males and 3 females,median age was 45 years.C-ALCL often presented with solitary skin nodule.Histologically,the lymphoma cells were infiltrated the dermis and subcutis in a sheet-like patter.They were of large size and showed conspicuous nuclear atypia.Immunohistochemical study showed the lymphoma cells were positive for CD30,ALK was noted in 2,and EMA in 3.CD3,CD4,CD45RO or TIA-1 were positive.CD20,S-100,HMB45,CK were negative.Conclusion C-ALCL was rare,it is helpful in diagnosis,differential diagnosis and prognosis for C-ALCL by understanding clinicopathologic and immunophenotypic features.
出处
《临床医学》
CAS
2010年第8期25-26,共2页
Clinical Medicine
关键词
皮肤间变性
淋巴瘤
大细胞
临床病理学特征
免疫组织化学
Cutaneous anaplastic
Lymphoma
large cell
Clinicopathologic features
Immunohistochemisty
