摘要
以小鼠骨髓嗜多染红细胞微核率（ＰＣＥＭＮＲ）和骨髓有核细胞数为指标对发酵黄腐酸（ＢＦＡ）和矿源黄腐酸（ＭＦＡ）进行了致突变作用和对造血系统影响的检测。检测结果表明：ＢＦＡ和ＭＦＡ本身无诱变性，可作为食品添加剂、饲料添加剂及药品使用。而且在给小鼠致变剂环磷酰胺时，ＢＦＡ可抑制突变率，保护分裂细胞，提高造血机能，并有一定的正向量效关系，在较大量使用时无毒副作用。ＭＦＡ也可抑制突变，保护分裂细胞，但在较大剂量时有一定的负向效应。故二者可在一定范围内减少环磷酰胺造成的造血机能下降和突变率上升等毒副作用，可作为化疗辅助用药。
The study was designed to compare effects of anti inflammatory and analgesia with biochemistry fulvatum acid (BFA) and mineral fulvatum acid (MFA).The results showed that BFA has much curative effects and less toxicity than MFA in the experiments of acute inflammation and chromic inflammation of mice and rats.The effects of anti inflammatory and analgesia of BFA was as same as capsulae indomethacini and carbaslatum calcicum.BFA can be used to take the place of MFA in medicines. [
出处
《北京联合大学学报》
CAS
1999年第2期69-72,共4页
Journal of Beijing Union University
