摘要
胃癌是消化系统常见的恶性肿瘤之一,由于早诊率低,大多数患者在诊断时已经处于疾病中晚期。化疗是进展期胃癌的重要治疗方法,但是细胞毒性药物联合方案,并没有从根本上提高化疗有效率。分子靶向治疗是近年来在治疗血液系统肿瘤和实体瘤中涌现出的新治疗手段。随着对胃癌发生、发展和转移过程中分子生物学机制的研究,这种治疗手段也逐步应用于胃癌治疗的临床实践。这些靶向治疗策略主要包括:HER2单克隆抗体、表皮生长因子受体抑制剂、血管生成抑制剂、多靶点酪氨酸激酶抑制剂、细胞周期蛋白依赖性激酶(CDKs)、mTOR抑制剂、c-M et抑制剂、基质金属蛋白酶抑制剂、IGF-1R抑制剂、HSP 90抑制剂等。文中就近年来进展期胃癌分子靶向治疗的研究结果及相关进展做一综述。
Gastric cancer is one of the most common malignancies in the digestive system.Due to the low rate of early diagnosis,most of the patients with gastric cancer have advanced disease at the time of diagnosis.Chemotherapy is still the mainstay of the treatment for advanced gastric cancer,however,the efficacy of combined cytotoxic drugs was not improved completely.Molecular targeted therapies have emerged as a novel approach to the treatment of both hematological and solid tumors in recent years.The study of molecular mechanisms underlying the formation,progression and metastasis in advanced gastric cancer has enabled us to use the new approach to treat this disease in clinical practice.These therapeutic strategies include targeting EGFR signal transduction pathway,HER2 monoclonal antibody,anti-angiogenetic agents,multityrosine kinase inhibitors,cyclin dependent kinase（CDK） inhibitors,c-Met inhibitors,PI3k/Akt/mTOR pathway inhibitors,matrix metalloproteinase inhibitors,IGF-1R inhibitors,and HSP 90 inhibitors.The aim of this review was to summarize the most recent publications on targeted therapies for advanced gastric cancer.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2010年第17期1531-1538,共8页
Chinese Journal of New Drugs
