摘要
目的了解杭州地区白细胞减少症感染金黄色葡萄球菌的临床分布及耐药趋势。方法分析杭州地区2007-2009年白细胞减少症感染金黄色葡萄球菌的临床分布、分离及耐药状况。结果分离出的797株金黄色葡萄球菌标本主要来源于呼吸道痰液(61.4%),其次分别为皮肤和伤口分泌物(18.3%)、血液(12.5%);对常用抗菌药物均有较高耐药,但对万古霉素敏感率为100.0%;同时对苯唑西林、庆大霉素、红霉素、左氧氟沙星、四环素耐药的菌株占88.5%,是主要耐药模式,侵入性操作(51.9%)和老年(26.8%)是最常见易感因素。结论白细胞减少症感染金黄色葡萄球菌的分离率和耐药率均有较明显逐年上升趋势,必须加强管理抗菌药物合理使用和严格消毒隔离措施。
OBJECTIVE To investigate the clinical characteristics and resistance of Staphylococcus aureus（SAU） infection so as to guide the treatment of S.aureus infection in leukopenia patients.METHODS The data of leukopenia patients who suffered SAU infection from Jan 2007 to Dec 2009 were collected,clinical characteristics and risk factors were analyzed,and the sensitivity of isolated strains to antibacterial agents was detected.RESULTS Sputum（61.4%）,excreta（18.3%） and blood（12.5%） were the main specimen sources of SAU.Except the sensitive rate to vancomycin was 100%,MRSA remained the high drug resistance rate to other drugs.88.5% of meticillin-resistant SAU were isolated,including resistant to gentamicin,erythromycin,levofloxacin and tetracycline,and it was the most common bacterial resistance model.The main risk factors were invasive procedure（51.9%） and the elderly（26.8%）.CONCLUSION Both the drug resistant rate and the isolated rate of SAU causing leukopenia infection keep an upward tendency.So the rational application of antibiotics and the disinfection measures should be strengthened.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第18期2877-2879,共3页
Chinese Journal of Nosocomiology
基金
浙江省杭州市科技局资助项目(2007B0022)
