摘要
目的评估迷走神经移位膈神经重建呼吸功能在高位颈髓损伤大鼠中的效果。方法成年雌性SD大鼠(180～220g,30只)被分为实验组(20只)和对照组(10只)。实验组的大鼠行单侧迷走神经移位膈神经。对照组的大鼠行单侧膈神经与迷走神经显露、离断并游离。实验观察时间为6周。结果手术后大鼠的一般健康状况正常。肌电图显示潜伏期移植侧为(2.81±0.99)CV,健侧为(1.67±0.40)CV,波幅移植侧为(1.59±0.31)mV,健侧为(23.5±14.68)mV。呼吸频率移植侧为(87±14.46)次/分,健侧为(90±19.37)次/分。在C2横断后移植侧膈肌仍能继续工作(89.36±41.88)s。结论迷走神经移位膈神经可能是一种有效的重建高位颈髓损伤后呼吸功能的治疗方法。
Objective To evaluate the effect of the vagus to phrenic nerve transfer on recovery of respiratory function in high cervical cord transeeted adult rats.Methods One experimental（n=20） and one control groups（n=10） of adult Sprague-Dawley female rats （180- 220 g,n=30） were employed. In the experimental group, animals were subjected to the vagus to phrenic nerve transfer unilaterally. In the control animals, the vagus and the phrenic nerve were unilaterally exposed, and the two nerves were excised and left free. All of the animals were allowed to recover for 6 weeks.Results The rats general state of health after the surgery was normal. The motor evoked potentials showed that the latency period was （2.81±0.99） CV of the transfer side and （1.67±0.40） CV of the normal side, and the amplitude was （1.59±0.31） mV of the transfer side and （23.5±14.68） mV of the normal side. The respiratory rate was （87±14.46） epm of the transfer side and （90±19.37） cpm of the normal side. After C2 transection the diaphragm of the transfer side could work for （89.36±41.88） s when the normal stopped working. Conclusion The vagus to phrenie nerve transfer may be a useful therapeutic modality on recovery of respiratory function in high cervical cord injury.
出处
《中国骨与关节损伤杂志》
2010年第9期797-799,共3页
Chinese Journal of Bone and Joint Injury
关键词
颈髓损伤
功能重建
呼吸系统
神经移植
膈神经
迷走神经
Cervical spinal cord injury
Functional recovery
Respiration
Nerve transfer
Phrenic nerve
Vagus nerve
