摘要
转铁蛋白可经聚合物、脂质体等与抗肿瘤药物结合,通过转铁蛋白-转铁蛋白受体特异结合途径,可不同程度延长药物血浆半衰期,降低药物的毒副作用,提高药物在肿瘤组织的蓄积量,从而提高药物的主动靶向活性。因此,转铁蛋白可作为一种新型的药物主动靶向载体,在肿瘤靶向治疗中有广阔的应用前景。
Transferrin combined with anticancer drugs by polymers,liposomes and through the transferrin-receptor-specific binding means,can extend plasma half-life of drugs at different degrees,reduce the toxic effects of drugs,increase drug accumulation in tumor tissues and subsequently enhance the drug activity of initiative targeting.Thus,transferrin can be used as a novel drug carrier for initiative targeting therapy and has a promising prospect in cancer therapy.
出处
《国际病理科学与临床杂志》
CAS
2010年第4期359-362,共4页
Journal of International Pathology and Clinical Medicine
