摘要
目的:为了验证疾病缩减效应假说:中药复方天然组合化学库中的多种有效成分,在一定的有效药物浓度范围内,以低于其某一单体成分治疗剂量进入人体后,有选择地反复作用于与某种疾病有关的多个直接靶点或间接靶点,此后,以整合、协同等形式,通过"疾病缩减效应",达到治疗疾病、减轻病痛的药理作用。方法:选用大鼠束缚寒冷应激性胃溃疡模型,以溃疡指数、胃液游离酸、总酸度、胃泌素等为指标,考察理中丸及其拆方的抗胃溃疡效果。结果:理中汤组、人参组和白术组与模型组对比溃疡指数、游离酸与总酸度有显著性差异,理中汤组理论疾病残留度为0.372,实际疾病残留度为0.320,理论值与实际值十分的接近。结论:表明了理中丸可能通过多成分多靶点的整合、协同作用达到了对抗消化性溃疡的效果,证实了中药复方疾病缩减效应的客观存在。
This work aimed to verify the hypothesis of ＂cutting-down-effect of diseases＂. When active components from the diversiform natural chemical components warehouse of compound prescriptions enter into human bodies at each ingredient＇s therapeutic dosage in a certain effective concentration range, they will selectively and repeatedly act on direct and indirect targets specific for a certain kind of disease, and then achieve their pharmacological effects of healing the disease or relieving the pain through ＂cutting-down-effect of diseases＂ in such forms as synergy and integration. In this work, the rat gastric ulcer models with constraint and cold stress were chosen to investigate the anti-peptic gastric ulcer effects of Lizong Pill and its separated prescription in terms of ulcer index, free acid and total acidity in gastric juice. The results showed that the ulcer index, free acid and total acidity of the Lizong Pill group, Ginseng group and largehead atractylodes rhizome group were significantly different from those of the model group. The theoretical disease residual rate of the Lizong Pill group was 0.372, while the practical disease residual rate was 0.320, quite similar to each other. Thus, the Lizong Pill may achieve the anti-peptic gastric ulcer effects via the synergy and integration of muhicomponents and multi-targets, thus verifying the scientific hypothesis of ＂cutting-down-effect of diseases＂.
出处
《世界科学技术-中医药现代化》
2010年第4期580-584,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金面上项目(30472126):中药复方多靶点作用的反证及其模式建立的实验研究
负责人:吴水生
关键词
中药复方
多靶点
消化性溃疡
科学假设疾病缩减效应
Compound prescription of Chinese herbs, Multi-target, Peptic ulcer Scientific hypothesis, Cutting-downeffect of Diseases
