摘要
目的了解梅毒螺旋体(TP)外膜脂蛋白抗原TP15、TP17、TP42、TP47相关特异性抗体,在一期和二期梅毒病人血清中的检出状况,评价其在早期梅毒血清学诊断应用的意义。方法用线性免疫分析(Lineimmunoas-say)方法对24例一期梅毒病人,54例二期梅毒病人的血清进行检测,分析TP15、TP17、TP42、TP47相关特异性抗体与临床特征及传统血清学方法检测结果的关系。结果一期梅毒病人血清中,TP15、TP17、TP42、TP47的抗体阳性率分别为29.2%、100.0%、91.7%和95.8%,二期梅毒病人血清中TP15抗体阳性率为87.0%,TP17、TP42和TP47抗体均为100.0%。结论梅毒螺旋体外膜脂蛋白抗原特异性抗体产生与感染时间相关,TP17抗体出现最早,在一期和二期梅毒病人血清中,TP42和TP47抗体也均有高的阳性率,TP15抗体在二期梅毒病人血清中的阳性率较一期梅毒病人显著增高。
Objective To detect the specific antibodies to the Treponema pallidum antigen TP15,TP17,TP42（Tmp A）and TP47 in primary and secondary syphilitic patients,and evaluate their values for the diagnosis of early syphilitic infection.Methods Line immunoassay was used to detect anti-TP15,anti-TP17,anti-TP42 and anti-TP47 antibodies in the serum of 24 patients with primary syphilis and 54 patients with secondary syphilis.Results The anti-TP15 antibody was detected in 29.2% of primary syphilitic patients,and the positive rates of anti-TP17,anti-TP42 and anti-TP47 antibodies were 100%,91.7% and 95.8% respectively in primary syphilitic patients.In the secondary syphilitic patients,the positive rate of anti-TP15 antibody was 87%;and 100% of the secondary syphilitic patients were detected positive for anti-TP17,anti-TP42 and anti-TP47 antibodies.Conclusion Anti-TP17,anti-TP47 and anti-TP42 antibodies had high positive rate in both primary and secondary syphilitic patients.The positive rate of anti-TP15 antibody was lower in patients with primary syphilis and significantly increased in patients with secondary syphilis.
出处
《中国艾滋病性病》
CAS
2010年第4期390-392,418,共4页
Chinese Journal of Aids & STD
基金
北京市科委艾滋病综合防治项目(编号:0906003040291)~~
