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乳腺梭形细胞癌15例临床及病理分析 被引量:1

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摘要 目的探讨乳腺梭形细胞癌的生物学特点和预后。方法回顾性分析15例乳腺梭形细胞癌的临床及病理形态特点、免疫组织化学特征。结果病理形态上≥80%区域为梭形(肉瘤样)形态,所有病例均至少呈一种细胞角蛋白阳性,其中阳性率最高的细胞角蛋白抗体包括Pan-CK(14/15,93.3%)和CK14(6/8,75%),其次是AE1/AE3(4/10,40%)、CK8/18(2/5,40%)和EMA(6/13,46.2%)。6例(40%)同时表达p63、CK14和SMA,提示向肌上皮分化。结论纯粹的梭形细胞癌较之普通型乳腺导管癌的淋巴结转移率要低得多。免疫组化分析时须使用一组细胞角蛋白抗体,包括CK14、pan-CK、AE1/AE3、34βE12等以证实或排除其上皮性来源。
作者 徐军
机构地区 武义县人民医院
出处 《浙江实用医学》 2010年第4期302-303,333,共3页 Zhejiang Practical Medicine
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