摘要
目的评价13Ⅰ1治疗Graves′病的临床疗效及影响疗效的因素。方法对13Ⅰ1治疗的119例Graves′病患者进行随访,分析疗效与年龄、性别、病程、治疗前三碘甲状腺原氨酸(T3)及甲状腺素(T4)水平、甲状腺质量、甲状腺球蛋白抗体(TGAb)和甲状腺过氧化物酶抗体(TPOAb)、甲状腺最高摄碘率、摄碘量、抗甲状腺药物治疗等因素的关系。使用PEMS3.1统计软件进行单因素及多因素分析,探寻影响13Ⅰ1治疗Graves′病临床疗效的因素。结果 119例患者中,痊愈41例(34.5%),好转35例(29.4%),11例(9.2%)无效,甲减32例(26.9%),总有效率为90.8%。疗效主要与甲状腺质量(大小)及甲状腺最高摄碘率有关(P<0.05)。结论 13Ⅰ1治疗Graves′病有效率高。甲状腺质量小、最高摄碘率相对较低的患者13Ⅰ1治疗效果好。
Objective To investigate the therapeutic effect of 131Ⅰ treatment on Graves′ hyperthyroidism and its influencing factors.Methods A total of 119 Graves′ disease patients receiving 131Ⅰ treatment were followed up,and the relationship of therapeutic effects to age,gender,disease duration,pre-treatment levels of triiodothyronine （T3） and thyroxine （T 4）,thyroid mass,thyroid globulin antibody （TGAb）,thyroid peroxidase antibody （TPOAb）,maximum iodine uptake rate,iodine absorption,antithyroid drug treatment,etc.were analyzed.PEMS 3.1 statistical software was used to perform univariant or multivariant analyses to investigate the factors influencing the therapeutic effect of 131Ⅰ treatment on Graves′ disease.Results Of 119 patients,41 were cured （34.5%）,35 improved （29.4%）,11 had no response （9.2%）,32 had hypothyroidism （26.9%）,the total clinical efficacy rate was 90.8%.The effects were mainly related to thyroid mass （sizes） and maxiamum iodine uptake rate （P0.05）.Conclusion Treatment of 131Ⅰ for Graves′ disease,more effective for patients with smaller thyroid masses and lower maximum iodine intake rate,is of high effective rate.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第23期2564-2566,共3页
Chinese General Practice
基金
新疆维吾尔自治区重点学科(内科学)建设经费(2004-2008)
