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紫杉烷类化疗所致重度中性粒细胞减少的影响因素及护理对策 被引量:2

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摘要 目的探讨紫杉烷类化疗所致重度中性粒细胞减少的影响因素及护理对策。方法回顾性分析2009年4—12月在我院进行紫杉烷类化疗的87例恶性肿瘤患者,31例(35.6%)患者出现远处转移,24例(27.6%)患者合并有高血压、糖尿病或肝脏疾病。所有患者化疗前血常规检查均正常,并都接受了含紫杉烷类药物(紫杉醇、多西紫杉醇、紫杉醇酯质体)的化疗。重度中性粒细胞减少患者经积极的药物治疗、各项综合护理措施均顺利度过了危险期。对第1周期化疗后的中性粒细胞减少情况及其可能的影响因素进行分析,中性粒细胞减少程度采用世界卫生组织(WHO)毒副反应标准进行分级。结果35例(40.2%)患者出现重度(3级和4级)中性粒细胞减少,15例(17.2%)患者出现粒细胞缺乏性发热。无一例患者合并感染或因重度中性粒细胞减少而死亡。既往曾化疗、伴发其他疾病的患者易发生重度中性粒细胞减少(P〈0.05)。结论既往曾化疗、伴发其他疾病的患者易发生重度中性粒细胞减少,系统、规范的护理在其处理中起重要作用。
出处 《中华现代护理杂志》 2010年第22期2663-2665,共3页 Chinese Journal of Modern Nursing
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