摘要
目的:探讨血N-末端脑钠肽前体(NT-proBNP)水平对老年急性呼吸困难患者的诊断价值。方法:用电化学发光免疫法测定96例老年急性呼吸困难患者血浆NT-proBNP,包括心源性呼吸困难和肺源性呼吸困难,比较2种急性呼吸困难患者、健康体检者血浆NT-proBNP水平,同时比较心源性呼吸困难组不同心功能分级(NYHA)患者的血NT-proBNP水平。结果:心源性呼吸困难患者血NT-proBNP水平明显高于肺源性呼吸困难组患者(P<0.01);心源性呼吸困难组血NT-proBNP水平在心功能不同级别间差异有显著性意义,与左室射血分数(LVEF)呈负相关。结论:血NT-proBNP水平有助于心源性与肺源性呼吸困难患者的鉴别诊断,特别在老年患者病情危重复杂,需要短时间内明确病因时,通过监测血NT-proBNP水平可能有助于鉴别。
Objective： To investigate the value of serum level of NvproBNP in diagnosis of patients with acute dyspnea. Methods： The serum level of Nt-proBNP in 96 patients with acute dyspnea including cardiac aspnea and pulmonary aspnea were measured by ELISA. The serum level of Nt-proBNP was compared between patients with 2 different aspnea and healthy people, meanwhile, serum level of Nt-proBNP was compared between different cardiac function in cardiac aspnea group. Results： The serum level of Nt-proBNP was significantly higher in patients with cardiac aspnea than that in pulmonary aspnea （P〈0. 01）. The serum level of Nt- proBNP was significantly different in different stages of heart function in cardiac aspnea group, and negatively correlated with left ventricular ejection fraction （LVEF）. Conclusions： Serum NT-proBNP contributes to differ ential diagnosis of cardiac and pulmonary dyspnea, especially for elderly patients in critical and complex condi tion, requiring a clear cause in short time.
出处
《内科急危重症杂志》
2010年第4期199-200,202,共3页
Journal of Critical Care In Internal Medicine
