摘要
目的探讨老年性痴呆患者血浆胆碱酯酶(cholinesterase,ChE)活性改变在临床上的应用。方法分别测定30例散发阿尔茨海默病(sporadic Alzheimer’s disease,SAD)和34例血管性痴呆(Vascular dementia,VD)患者及36例正常老年人空腹血浆ChE活性水平。结果散发阿尔茨海默病(4160±1048U/L)和血管性痴呆(5436±1722U/L)患者血浆ChE平均水平比正常老年人明显降低(5436±1722U/L),差异有统计学意义(P<0.001);散发阿尔茨海默病患者血浆ChE活性亦较血管性痴呆患者降低,差异有统计学意义(P<0.02)。结论老年性痴呆患者血浆ChE活性较正常老年人明显降低,SAD患者血浆ChE活性较VD患者亦明显减低。
Objective To investigate the activities of cholinesterase of the patients with dementia and the normal aged and to explore the significance of their activities in the clinical diagnosis value1 Methods The activities of plasma ChE from patients with 30 SAD and 34 VD and 36 the normal aged were detected.Results The level of plasma ChE activity（4160±1048）U/L in SAD and（5436±1722）U/L in VD was significantly lower than that in normal controls（7238±1289）U/L,P〈0.001 ;while there was significant difference in plasma ChE activity between SAD and VD,P0〈.002.Conclusion Plasma ChE activity in dementia patients（5436±1722U/L） are significantly lower than that in normal aged,and plasma ChE activity in SAD patients are significantly lower than that in VD patients.
出处
《当代医学》
2010年第22期82-83,共2页
Contemporary Medicine
关键词
散发阿尔茨海默病
血管性痴呆
胆碱酯酶
Sporadic Alzheimer＇s disease
Cholinesterase
Vascular dementia
