摘要
目的探讨血清Ⅲ型前胶原(TypeⅢ Collagen,PCⅢ)对肝纤维化的诊断价值。方法采用增强电化学发光法测定92例各种病毒性肝炎患者及90例健康献血者血清PCⅢ水平,比较各组病毒性肝炎之间及健康献血者血清PCⅢ差异,结合病理结果进行分析。结果血清PCⅢ水平在慢性肝炎中度患者中明显升高,以慢性肝炎重度、肝硬化者为最高,3组患者与其他组比较,差异有统计学意义(P<0.01),其升高程度与肝纤维化及肝病严重程度呈正相关,但与肝内炎症、坏死程度无明显关系。结论动态测定血清PCⅢ水平,可作为反映慢性肝病肝纤维化严重程度和预后的指标。
Objective To explore the diagnostic value of serum PC Ⅲ in hepatic fibrosis.Methods The level of PC Ⅲ was detected in blood serum of 92 patients with various types of virus hepatitis and 90 healthy subjects by ECLI, which was analyzed between various groups＇hepatitis and controls, and then compared to the hepatic histological findings.Results The level of PCⅢ was obviously increased in the patients with moderate chronic hepatitis, most in patients with severe chronic hepatitis and hepatocirrhosis. There were significant differences between these three groups and other groups （P〈 0.01 ）.The increased level was positively related to the severity of hepatic fibrosis and liver disease, but not with the severity of inflammation and necrosis of liver.Conclusion Dynamic measurement of the level of PC Ⅲ in serum can be used as a reference index that reflects severity of hepatic fibrosis and prognosis of chronic liver disease.
出处
《中国疗养医学》
2010年第9期844-845,共2页
Chinese Journal of Convalescent Medicine
关键词
肝病
血清Ⅲ型前胶原
肝纤维化
Liver disease
Type Ⅲ pro-collagen peptide（PC Ⅲ ）
Hepatic fibrosis
