摘要
[目的]探讨鼻康喷雾剂的抗炎作用。[方法]采用小鼠耳廓致炎实验、大鼠蛋清足跖肿胀实验和大鼠棉球肉芽肿实验,设阳性和空白对照。[结果]鼻康喷雾剂空白对照组小鼠耳廓肿胀度(12.05±1.52)mg,鼻康喷雾剂大、中、小剂量组的小鼠耳廓肿胀度分别为(3.42±3.32)mg、(5.95±2.04)mg、(10.30±1.75)mg,与空白对照组比较有统计学意义(P<0.05或P<0.01);鼻康喷雾剂大、中、小剂量组在致炎后2h大鼠右后足跖肿胀度明显减小,4～6h时作用最为明显,与空白对照组比较有统计学意义(P<0.05或P<0.01);空白对照组大鼠肉芽肿质量为(224.99±83.09)mg/100g体质量,鼻康喷雾剂大、中、小剂量组大鼠肉芽肿质量分别为(144.61±25.82)mg/100g体质量、(163.78±21.49)mg/100g体质量、(210.42±69.60)mg/100g体质量,与空白对照组比较明显减小(P<0.05)。[结论]鼻康喷雾剂能够减轻二甲苯所致的小鼠耳廓肿胀度、减轻蛋清所致的大鼠右后足跖肿胀度、对大鼠棉球肉芽组织增生有抑制作用,有抗炎作用。
[Objective] To study the anti-inflammatory effect of Nasal Healing Spraying Agent（NHSA）.[Methods] We used the model of auricular swelling reaction in mice,the rat paw edema model reaction,and the Cotton Ball Granuloma reaction in rat.The animals were designed into blank and positive control groups.[Results] The degree of swelling of mice auricle of blank control group was 12.05±1.52 mg;The degrees of the high dose group,middle dose group,low dose group were 3.42±3.32 mg,5.95±2.04 mg,10.30±1.75 mg respectively,and were significant in statistic analysis（P0.05 or P0.01）;The rate of the right postal toes and ankle swelling of rat of the high dose group,middle dose group,low dose group were remarkably decreased 2 h after making inflammation,while the most significant was found at 4～6 h.They were statistically significant difference（P0.05 or P0.01） compared with the blank control group;The weight of granuloma in rats from the blank control group was 224.99 ±83.09 mg/100g weight;The weights of the high dose group,middle dose group,low dose group are 144.61±25.82 mg/100 g body weight,163.78±21.49 mg/100 g b.w.,210.42±69.60 mg/100 g b.w.respectively,and were significant statistically（P0.05）.[Conclusion] NHSA could abate the degree of swelling of mice auricle and had anti-inflammatory effect.It could abate the rate of the right postal toes and ankle swelling of rat and had anti-inflammatory effect.It could inhibit the formation of cotton ball granuloma in rats and had anti-inflammatory effect.NHSA had immunoregulatory function.
出处
《天津中医药》
CAS
2010年第4期331-333,共3页
Tianjin Journal of Traditional Chinese Medicine
基金
国家教育部科学技术研究重点项目(00167)
关键词
鼻康喷雾剂
小鼠耳廓致炎实验
大鼠蛋清足跖肿胀实验
大鼠棉球肉芽肿实验
抗炎
Nasal Healing Spraying Agent（NHSA）
the model of auricular swelling reaction in mice
the rat paw edema model reaction
the Cotton Ball Granuloma reaction in rat
anti-inflammatory
