摘要
目的：研究植物黄酮芹菜素对ＩＬ－１、脂多糖（ＬＰＳ）诱导软骨细胞产生一氧化氮（ＮＯ）的抑制作用。方法：ＩＬ－１，ＬＰＳ体外诱导兔软骨细胞产生ＮＯ。以一氧化氮合酶（ＮＯＳ）抑制剂Ｎ－硝基－Ｌ－精氨酸做对照，研究芹菜素对产生ＮＯ的抑制作用。结果和结论：芹菜素（３．１２５～２５μｍｏｌ／Ｌ）剂量依赖性地抑制ＩＬ－１或ＬＰＳ诱导的ＮＯ产生，其抑制作用强于Ｎ－硝基－Ｌ－精氨酸。
Objective: To study the effect of plant flavonoid apigenin on NO production in chondrocytes induced by IL1 and LPS. Methods: IL1 and LPS induced NO production in rabbit chondrocytes. NnitroLarginine, a competitive NOS inhibitor was taken as control. The inhibitory effect of apigenin on NO production was observed. Results and Conclusion: Apigenin (3.125￣25 mol/L) dosedependently inhibited NO production, its effect is more intense than that of NnitroLarginines.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1999年第6期362-364,共3页
Academic Journal of Second Military Medical University
基金
国家自然科学基金
